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Vol. 56, No. 3, 2012
Issue release date: May–June
Section title: Novel Insights from Clinical Practice
Acta Cytologica 2012;56:325–329
(DOI:10.1159/000334201)

Dysplastic Megakaryocytes and Eosinophilic Precursors in the Diagnosis of Myeloid Sarcoma on Lymph Node Fine-Needle Aspiration Cytology: A Case Series

Ojha S.S. · Kothari K.S. · Naik L.P. · Fernandes G.C. · Rangwala S. · Agnihotri M.A.
Seth G.S. Medical College and King Edward Memorial Hospital, Mumbai, India

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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 8/30/2011 8:52:01 AM
Accepted: 10/4/2011
Published online: 4/26/2012
Issue release date: May–June

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 1

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY

Abstract

Objective: To analyze the cases diagnosed as myeloid sarcoma on fine-needle aspiration cytology (FNAC) of lymph nodes. Study Design: Ten cases of lymph node aspirate diagnosed as myeloid sarcoma were analyzed. FNAC was performed as a routine outpatient procedure in all cases. Correlation with peripheral smear, bone marrow examination, flow cytometry and cytogenetics was done wherever possible. Results: Diagnosis of a hematologic malignancy, before fine-needle aspiration, was available in only 2 cases. All 10 cases showed eosinophilic precursors while five aspirates showed megakaryocytes with dysplastic forms. Of the 10 cases, 3 were diagnosed as acute myeloid leukemia, 3 as chronic myeloid leukemia, 1 case as juvenile myelomonocytic leukemia, 1 case proved to be precursor T acute lymphoblastic leukemia/lymphoma and 2 patients did not show blasts on peripheral blood smear but showed blasts, dysplastic megakaryocytes and eosinophilic precursors in the aspirate. Conclusion: Thorough workup to search for an underlying hematological malignancy should be done whenever dysplastic megakaryocytes and/or eosinophilic precursors are seen in lymph node aspirate.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 8/30/2011 8:52:01 AM
Accepted: 10/4/2011
Published online: 4/26/2012
Issue release date: May–June

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 1

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY


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