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Table of Contents
Vol. 32, No. 4, 2011
Issue release date: February 2012
Section title: Original Research Article
Dement Geriatr Cogn Disord 2011;32:227–234
(DOI:10.1159/000334523)

Quality of Life and the Effect of Memantine in Dementia with Lewy Bodies and Parkinson’s Disease Dementia

Larsson V.a · Engedal K.c–e · Aarsland D.b, f · Wattmo C.a · Minthon L.a · Londos E.a
aClinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, and bKarolinska Institute, Huddinge, Sweden; cResearch Centre for Old Age Psychiatric Research, Innlandet Hospital Trust, Ottestad, dThe Norwegian Centre for Dementia Research, University Hospital Ullevaal and eFaculty of Medicine, University of Oslo, Oslo, and fPsychiatric Division, Section for Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: October 17, 2011
Published online: November 25, 2011
Issue release date: February 2012

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Aim: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias. Methods: A secondary analysis of a randomized controlled study in 70 patients with Parkinson’s disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer’s disease (AD) in domains according to the WHO’s classification of health. Results: Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure. Conclusion: This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: October 17, 2011
Published online: November 25, 2011
Issue release date: February 2012

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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