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Vol. 35, No. 1, 2012
Issue release date: January 2012
Section title: Original Report: Patient-Oriented, Translational Research
Am J Nephrol 2012;35:31–39
(DOI:10.1159/000334742)

Relationship between Magnesium and Clinical Biomarkers on Inhibition of Vascular Calcification

Salem S. · Bruck H. · Bahlmann F.H. · Peter M. · Passlick-Deetjen J. · Kretschmer A. · Steppan S. · Volsek M. · Kribben A. · Nierhaus M. · Jankowski V. · Zidek W. · Jankowski J.
aCharité, Medical Clinic IV, University of Berlin, Berlin, bUniversitätsklinikum Essen, Essen, cUniversitätsklinikum Homburg, Homburg, dFresenius Medical Care Deutschland GmbH, Bad Homburg, eNephrology, University of Düsseldorf, Düsseldorf, and fBayer HealthCare AG, Wuppertal, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: 10/18/2011
Accepted: 10/29/2011
Published online: 12/15/2011

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 2

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background: Arteriosclerosis and cardiovascular disease are strongly associated with vascular calcification. Hyperphosphatemia is an essential risk factor for increased vascular calcification. End-stage renal disease (ESRD) patients could serve as an in vivo model for accelerated calcification. This study focuses on the most likely protective effects of magnesium ion (Mg2+) on phosphate-induced vascular calcification ex vivo/in vitro. Furthermore, plasma Mg2+ concentrations of ESRD and healthy controls were investigated for association with surrogate parameters of vascular calcification in vivo. Methods: Aortic segments of male Wistar-Kyoto rats were incubated and the phosphate concentration of the medium was elevated. The aortic segments were incubated in the absence and presence of MgCl2; tissue calcification was quantified by different methods. Serum Mg2+ concentrations of patients with chronic kidney disease (CKD stage 5; ESRD) and patients without CKD (controls) were associated with carotid intima media thickness (IMT) and aortic pulse wave velocity (PWV) as surrogate parameter for arteriosclerosis and arterial stiffening. Results: Incubation of aortic segments in the presence of β-glycerophosphate and NaH2PO4 caused an increased tissue Ca2+ deposition compared to control conditions. This increased amount of Ca2+ in the aortic rings was significantly decreased in the presence of Mg2+. In CKD patients, but not in controls, magnesium serum concentration was associated with the IMT of the carotid arteries. In addition, CKD patients with higher magnesium serum concentration had a significantly lower PWV. Discussion and Conclusion: Elevated phosphate concentrations in the culture media induce ex vivo/in vitro medial calcification in intact rat aortic rings in the presence of alkaline phosphatase. Mg2+ ions reduced ex vivo/in vitro vascular calcification despite increased phosphate concentration. This hypothesis is additionally based on the fact that CKD patients with high Mg2 serum levels had significantly lower IMT and PWV values, which may result in a lower risk for cardiovascular events and mortality in these patients. Therefore, Mg2+ supplementation may be an option for treatment and prevention of vascular calcification resulting in a reduction of cardiovascular events in CKD patients.


  

Author Contacts

Prof. Dr. J. Jankowski
Charité-Universitätsmedizin Berlin, Medizinische Klinik IV (CBF)
Hindenburgdamm 30, DE–12200 Berlin (Germany)
Tel. +49 30 450 525 567
E-Mail Joachim.Jankowski@charite.de

  

Article Information

Received: October 18, 2011
Accepted: October 29, 2011
Published online: December 15, 2011
Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 2, Number of References : 43

  

Publication Details

American Journal of Nephrology

Vol. 35, No. 1, Year 2012 (Cover Date: January 2012)

Journal Editor: Bakris G. (Chicago, Ill.)
ISSN: 0250-8095 (Print), eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: 10/18/2011
Accepted: 10/29/2011
Published online: 12/15/2011

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 2

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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