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Table of Contents
Vol. 223, No. 4, 2011
Issue release date: March 2012
Section title: Original Paper
Dermatology 2011;223:330–334
(DOI:10.1159/000334778)

Treatment of Small Superficial Haemangioma with Timolol 0.5% Ophthalmic Solution: A Series of 20 Cases

Oranje A.P.a, d · Janmohamed S.R.a · Madern G.C.b · de Laat P.C.J.c
aDivision of Paediatric Dermatology, Department of Paediatrics, Erasmus MC – Sophia Children’s Hospital, KinderHaven, Havenziekenhuis Rotterdam, and Departments of bPaediatric Surgery and cPaediatrics, Erasmus MC – Sophia Children’s Hospital, and dDepartment of Dermatology, Maasstad Ziekenhuis, Rotterdam, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 05, 2011
Accepted: October 28, 2011
Published online: December 16, 2011
Issue release date: March 2012

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 2

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Haemangioma of infancy (HOI) on the face may be disfiguring and alarming for parents. Usually they are not treated when they are small. Treatment of HOI with propranolol is a breakthrough. Timolol (topical treatment) and propranolol are closely related. Methods: We considered topical treatment with timolol 0.5% ophthalmic solution 3–4 times daily in patients with small HOI. Twenty patients with small mostly superficial HOI were included. Results: A series of 20 patients with HOI treated with timolol 0.5% ophthalmic solution are described. The treatment was effective in all superficial HOIs after 1–4 months. A quick direct inhibitory effect on the growth of the HOI followed by slower regression was observed. The children had to be treated during the whole proliferative phase. Deep HOIs on the nose (2 cases) and lower eyelid (1 case) showed no response. Conclusion: Topical timolol 0.5% ophthalmic solution is effective in HOI. Safety and effectiveness of drugs like topical timolol and topical propranolol require further investigation but they seem very safe when used in small HOIs. We recommend that small superficial HOIs should be treated in an early proliferative phase.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 05, 2011
Accepted: October 28, 2011
Published online: December 16, 2011
Issue release date: March 2012

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 2

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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