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Vol. 56, No. 2, 2012
Issue release date: March–April
Section title: Gynecologic Cytopathology
Acta Cytologica 2012;56:160–165
(DOI:10.1159/000335145)

Implementing Human Papillomavirus Testing in a Public Health Hospital: Challenges and Opportunities

Beldi M.C.a · Tacla M.a · Caiaffa-Filho H.c · Ab’saber A.b · Siqueira S.b · Baracat E.C.a · Alves V.A.F.b, d · Longatto-Filho A.d, e
Departments of aObstetrics and Gynecology and bPathology, Clinics Hospital, cMolecular Biology Branch, Central Laboratory Division, Clinics Hospital, School of Medicine, and dLaboratory of Medical Investigation 14, Department of Pathology, Medical School, University of São Paulo, São Paulo, Brazil; eLife and Health Sciences Research Institute, School of Health Sciences, University of Minho, and PT Government Associate Laboratory, Braga, Portugal

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Article / Publication Details

First-Page Preview
Abstract of Gynecologic Cytopathology

Received: 7/27/2011 8:50:00 AM
Accepted: 11/14/2011
Published online: 2/17/2012
Issue release date: March–April

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY

Abstract

Objectives: Robust evidence now supports human papillomavirus (HPV) testing as a more effective option to screening and as more sensitive than cytology in detecting high-grade cervical intraepithelial neoplasia . Our goal was to analyze the performance of the Hybrid Capture II (HC2) assay for high-risk HPV (hrHPV) in women undergoing gynecological examination at a public health hospital as part of the evaluation of HPV screening as an alternative or complement to cytology. Study Design: This analysis is a subset of a cross-sectional study carried out at a large public hospital serving a predominantly low-resource population. A total of 705 women were enrolled; the sensitivity and specificity of each test were estimated and compared. Results: The analysis identified 272 hrHPV-positive women (mean age 36.3 years) and 433 hrHPV-negative women (mean age 41.2 years). HPV testing showed a significantly increased sensitivity of the HC2 assay versus cytology (84.5 vs. 69.7%; p < 0.0001) but a lower specificity (49.90 vs. 88.78%; p < 0.0001). Conclusion: The combination of both methods seems to be useful in improving detection of cervical lesions.

© 2012 S. Karger AG, Basel


  

Author Contacts

Correspondence to: Dr. Adhemar Longatto-Filho
Laboratory of Medical Investigation (LIM) 14
Faculty of Medicine, University of São Paulo
São Paulo 1246-903 (Brazil)
Tel. +55 11 3061 7413, E-Mail longatto16@hotmail.com

  

Article Information

Received: July 27, 2011
Accepted after revision: November 14, 2011
Published online: February 17, 2012
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 3, Number of References : 15

  

Publication Details

Acta Cytologica (The Journal of Clinical Cytology and Cytopathology)

Vol. 56, No. 2, Year 2012 (Cover Date: February 2012)

Journal Editor: Bibbo M. (Philadelphia, Pa.)
ISSN: 0001-5547 (Print), eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY


Article / Publication Details

First-Page Preview
Abstract of Gynecologic Cytopathology

Received: 7/27/2011 8:50:00 AM
Accepted: 11/14/2011
Published online: 2/17/2012
Issue release date: March–April

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY


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