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Table of Contents
Vol. 6, No. 6, 2011
Issue release date: December 2011
Section title: Case Report · Kasuistik
Free Access
Breast Care 2011;6:475–478

Fetal Renal Insufficiency Following Trastuzumab Treatment for Breast Cancer in Pregnancy: Case Report und Review of the Current Literature

Gottschalk I.a · Berg C.a,b · Harbeck N.c · Stressig R.d · Kozlowski P.d
aPränatalmedizin und Gynäkologische Sonographie, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe der Universität zu Köln, bBereich Pränatale Medizin, Universitätsfrauenklinik Bonn, cBrustzentrum, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe der Universität zu Köln, dpraenatal.de, Pränatal-Medizin und Genetik, Düsseldorf, Germany
email Corresponding Author

Dr. Ingo Gottschalk, Pränatalmedizin und Gynäkologische Sonographie, Klinik und Poliklinik, für Frauenheilkunde und Geburtshilfe der Universität zu Köln, Kerpenerstr. 34, 50931 Köln, Germany, Tel. +49 221 478-4975, Fax -4998, ingo.gottschalk@uk-koeln.de

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Some drugs are known for their fetal nephrotoxicity and should be avoided during pregnancy. We report on a pregnant woman suffering from breast cancer who received a weekly neoadjuvant trastuzumab (Herceptin®) therapy from 15 weeks of gestation onward, in addition to a 3-weekly carboplatin/docetaxel chemotherapy. Fetal renal insufficiency with anhydramnios and missing visualization of the fetal bladder developed at 21 weeks. After discontinuation of trastuzumab and repeated instillation of amniotic fluid, the amount of amniotic fluid remained stable after 24 weeks of gestation. After caesarean section at 34 weeks because of fetal growth restriction, the renal function of the neonate was normal postnatally. In accordance with the current literature, our case shows a reversible adverse effect of trastuzumab on the fetal renal function and confirms the current recommendation that trastuzumab in pregnancy should be avoided. In pregnancies exposed to trastuzumab, treatment should be discontinued and the fetus should be closely monitored, with particular attention to the amniotic fluid and the fetal bladder volume, as these reflect fetal renal function.

© 2011 S. Karger AG, Basel

Article / Publication Details

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Abstract of Case Report · Kasuistik

Published online: December 16, 2011
Issue release date: December 2011

ISSN: 1661-3791 (Print)
eISSN: 1661-3805 (Online)

For additional information: http://www.karger.com/BRC

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