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Vol. 60, No. 2, 2012
Issue release date: May 2012
Section title: Original Paper
Ann Nutr Metab 2012;60:157–168
(DOI:10.1159/000335470)

Effect of L-Arginine and Selenium Added to a Hypocaloric Diet Enriched with Legumes on Cardiovascular Disease Risk Factors in Women with Central Obesity: A Randomized, Double-Blind, Placebo-Controlled Trial

Alizadeh M.a · Safaeiyan A.b · Ostadrahimi A.c · Estakhri R.d · Daneghian S.e · Ghaffari A.e · Gargari B.P.c
aDepartment of Biochemistry and Nutrition, School of Medicine, Urmia University of Medical Sciences, Urmia, bDepartment of Vital Statistics and Epidemiology and cDepartment of Biochemistry and Nutrition, Faculty of Health and Nutrition, Nutrition Research Center, dLiver and Gastrointestinal Disease Research Center, and eStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/12/2011
Accepted: 11/25/2011
Published online: 4/18/2012
Issue release date: May 2012

Number of Print Pages: 12
Number of Figures: 1
Number of Tables: 4

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Background/Aims: We aimed to discover if L-arginine and selenium alone or together can increase the effect of a hypocaloric diet enriched in legumes (HDEL) on central obesity and cardiovascular risk factors in women with central obesity. Methods: This randomized, double-blind, placebo-controlled trial was undertaken in 84 premenopausal women with central obesity. After a 2-week run-in period on an isocaloric diet, participants were randomly assigned to a control diet (HDEL), L-arginine (5 g/day) and HDEL, selenium (200 µg/day) and HDEL or L-arginine, selenium and HDEL for 6 weeks. Cardiovascular risk factors were assessed before intervention and 3 and 6 weeks afterwards. Results: After 6 weeks, L-arginine had significantly reduced waist circumference (WC); selenium had significantly lowered fasting concentrations of serum insulin and the homeostasis model assessment of insulin resistance index; the interaction between L-arginine and selenium significantly reduced the fasting concentration of nitric oxides (NOx), and HDEL lowered triglycerides (TG) and WC and significantly increased the fasting concentration of NOx. HDEL reduced high-sensitivity C-reactive protein levels in the first half of the study and returned them to basal levels in the second half. Conclusion: These data indicate the beneficial effects of L-arginine on central obesity, selenium on insulin resistance and HDEL on serum concentrations of NOx and TG.

© 2012 S. Karger AG, Basel


  

Author Contacts

Bahram Pourghassem Gargari, MSc, PhD
Nutrition Research Center, Department of Biochemistry and Nutrition
Faculty of Health and Nutrition, Golgasht St, Attar-e-Neishabury St
PO Box 5166614711, Tabriz (Iran)
Tel. +98 41 1337 6229, E-Mail pourghassemb@tbzmed.ac.ir

  

Article Information

Received: April 12, 2011
Accepted after revision: November 25, 2011
Published online: April 18, 2012
Number of Print Pages : 12
Number of Figures : 1, Number of Tables : 4, Number of References : 69

  

Publication Details

Annals of Nutrition and Metabolism

Vol. 60, No. 2, Year 2012 (Cover Date: May 2012)

Journal Editor: Koletzko B. (Munich)
ISSN: 0250-6807 (Print), eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/12/2011
Accepted: 11/25/2011
Published online: 4/18/2012
Issue release date: May 2012

Number of Print Pages: 12
Number of Figures: 1
Number of Tables: 4

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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