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Table of Contents
Vol. 31, No. 2, 2012
Issue release date: March 2012
Section title: Original Paper
Fetal Diagn Ther 2012;31:109–114
(DOI:10.1159/000335677)

First-Trimester Screening for Neural Tube Defects Using Alpha-Fetoprotein

Bredaki F.E.a · Poon L.C.a · Birdir C.a · Escalante D.a · Nicolaides K.H.a, b
aHarris Birthright Research Centre of Fetal Medicine, King’s College Hospital, and bDepartment of Fetal Medicine, University College Hospital, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 25, 2011
Accepted: December 02, 2011
Published online: February 29, 2012
Issue release date: March 2012

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 3

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

Objective: To assess the potential value of maternal serum alpha-fetoprotein (AFP) at 11–13 weeks’ gestation in early screening for fetal neural tube defects (NTDs). Methods: Maternal serum AFP at 11–13 weeks’ gestation was measured in 32 cases of fetal NTDs, including 18 cases of acrania and 14 cases of spina bifida, and 1,500 unaffected controls. The measured serum AFP was converted into multiple of the expected median (MoM) after adjustment for gestational age and maternal characteristics and Mann-Whitney test was used to determine the significance of difference in the mean MoM of serum AFP in the NTD group to that in the controls. Results: The mean AFP MoM in the NTD group (1.76, 95% CI 1.39–2.23) was significantly higher than in the controls (p < 0.0001). The mean AFP MoM was not significantly different between the cases of acrania and cases of spina bifida (1.78 vs. 1.75; p = 0.722). The detection rates of NTD in screening by serum AFP were 50.0% (95% CI 31.9–68.1) and 37.5% (95% CI 21.1–56.3) at fixed false-positive rates of 10 and 5%, respectively. Conclusion: Measurement ofmaternal serum AFP at 11–13 weeks’ gestation may be useful in screening for fetal NTDs.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 25, 2011
Accepted: December 02, 2011
Published online: February 29, 2012
Issue release date: March 2012

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 3

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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