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Vol. 90, No. 2, 2012
Issue release date: April 2012
Section title: Clinical Study
Stereotact Funct Neurosurg 2012;90:84–91
(DOI:10.1159/000335706)

Five-Year Follow-Up of 10 Patients Treated with Globus Pallidus Internus Deep Brain Stimulation for Segmental or Multisegmental Dystonia

Sarubbo S. · Latini F. · Quatrale R. · Sensi M. · Granieri E. · Cavallo M.A.
Divisions of aNeurosurgery and bNeurology, Department of Neurosciences and Rehabilitation, and cSection of Neurology, Department of Medical Surgical Sciences of Communication and Behavior, University Hospital S. Anna, Ferrara, Italy

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 4/5/2011 5:55:02 PM
Accepted: 12/11/2011
Published online: 2/17/2012

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN

Abstract

Introduction: Globus pallidus internus (GPi) deep brain stimulation (DBS) represents a validated, effective, and safe treatment for patients affected by generalized dystonia resistant to conservative treatment. Segmental and multisegmental dystonia have more recently been proposed as further indications for GPi DBS despite the lack of long-term homogenous follow-up. Here we present an original and detailed long-term follow-up (5 years) of a homogeneous population of 11 patients affected by segmental or multisegmental dystonia. Materials and Methods: Ten patients underwent bilateral GPi DBS electrode implantations under a Leksell stereotactic guide, with intraoperative neurophysiological monitoring. The follow-ups at 1, 3 and 5 years were collected using video-BFMDRS for motor and disability scores. The statistical analysis of the results is provided. Results: We reported a statistically significant improvement in motor and disability overall scores until 5 years after treatment. At the last follow-up, even the single motor subitems were statistically improved. Discussion: We observed a continuous and statistically significant improvement in all of the motor subitems and in the overall disability score until the 3-year follow-up. These results did not improve any further but they appeared steady at the last follow-up. We also report a significant improvement in the cranial-cervical subitems. Conclusions: GPi DBS should definitely be considered a safe and effective treatment also for segmental and multisegmental dystonia even in cases of relevant or prevalent cranial-cervical involvement.


  

Author Contacts

Silvio Sarubbo, MD
Division of Neurosurgery, Department of Neurosciences and Rehabilitation
‘S. Anna’ University Hospital, 203, C.so Giovecca
IT–44100 Ferrara (Italy)
Tel. +39 053 223 6815, E-Mail silviosarubbo@gmail.com

  

Article Information

Received: April 5, 2011
Accepted after revision: December 11, 2011
Published online: February 17, 2012
Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 2, Number of References : 34
Additional supplementary material is available online - Number of Parts : 1

  

Publication Details

Stereotactic and Functional Neurosurgery

Vol. 90, No. 2, Year 2012 (Cover Date: April 2012)

Journal Editor: Roberts D.W. (Lebanon, N.H.)
ISSN: 1011-6125 (Print), eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 4/5/2011 5:55:02 PM
Accepted: 12/11/2011
Published online: 2/17/2012

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN


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