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Vol. 28, No. 6, 2011
Issue release date: 2011
Free Access
Cell Physiol Biochem 2011;28:1079–1088

Life and Death of Lymphocytes: A Volume Regulation Affair

Bortner C.D. · Cidlowski J.A.
The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, North Carolina


The loss of cell volume, termed apoptotic volume decrease (AVD) has been a hallmark feature of apoptosis. However the role of this characteristic attribute of programmed cell death has always been questioned as to whether it plays an active or passive factor during apoptosis. Here we review studies that suggest that AVD plays an active role during apoptosis and the underlying flux of ions that results in this morphological event regulates the programmed cell death process.

 goto top of outline Author Contacts

John A. Cidlowski
Lab of Signal Transduction, National Institute of Environmental Health Sci,
National Institutes of Health, Department of Health and Human Services,
111 T. W. Alexander Dr., Research Triangle Park, North Carolina (USA)
Tel. +1919541-1594, Fax +1919541-1367, E-Mail

 goto top of outline Article Information

Accepted: December 09, 2011
Published online: December 16, 2011
Number of Print Pages : 10

 goto top of outline Publication Details

Cellular Physiology and Biochemistry (International Journal of Experimental Cellular Physiology, Biochemistry andPharmacology)

Vol. 28, No. 6, Year 2011 (Cover Date: 2011)

Journal Editor: F. Lang, Tübingen
ISSN: 1015–8987 (Print), eISSN: 1421–9778 (Online)

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