The loss of cell volume, termed apoptotic volume decrease (AVD) has been a hallmark feature of apoptosis. However the role of this characteristic attribute of programmed cell death has always been questioned as to whether it plays an active or passive factor during apoptosis. Here we review studies that suggest that AVD plays an active role during apoptosis and the underlying flux of ions that results in this morphological event regulates the programmed cell death process.
John A. Cidlowski
Lab of Signal Transduction, National Institute of Environmental Health Sci,
National Institutes of Health, Department of Health and Human Services,
111 T. W. Alexander Dr., Research Triangle Park, North Carolina (USA)
Tel. +1919541-1594, Fax +1919541-1367, E-Mail firstname.lastname@example.org
Accepted: December 09, 2011
Published online: December 16, 2011
Number of Print Pages : 10
Cellular Physiology and Biochemistry (International Journal of Experimental Cellular Physiology, Biochemistry andPharmacology)
Vol. 28, No. 6, Year 2011 (Cover Date: 2011)
Journal Editor: F. Lang, Tübingen
ISSN: 1015–8987 (Print), eISSN: 1421–9778 (Online)
For additional information: http://www.karger.com/journals/cpb
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