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Vol. 10, No. 1-4, 2012
Issue release date: April 2012
Section title: Paper
Neurodegenerative Dis 2012;10:187–190
(DOI:10.1159/000335909)

Prevalence and Profile of Mild Cognitive Impairment in Parkinson’s Disease

Monastero R. · Di Fiore P. · Ventimiglia G.D. · Ventimiglia C.C. · Battaglini I. · Camarda R. · Camarda C.
Laboratory of Epidemiology and Psychology of Aging and Dementia (LEPAD), Department of Experimental Biomedicine and Clinical Neuroscience (BioNeC), University of Palermo, Palermo, Italy

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 5/19/2011 3:34:06 PM
Accepted: 12/18/2011
Published online: 3/6/2012
Issue release date: April 2012

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD

Abstract

Background/Aims: The frequency of mild cognitive impairment (MCI) in Parkinson’s disease (PD) ranges from 19 to 40%, and this is probably due to methodological differences between the studies. The aim of this study was to evaluate the frequency and profile of MCI in a large sample of nondemented PD subjects and neurologically healthy subjects (NHS). Methods: A total of 872 subjects (582 controls and 290 PD) were included. The association between MCI and PD was tested, using logistic regression models; odds ratios (OR) with 95% confidence intervals (CI) were calculated. Results: Fifty-three percent of PD subjects and 45% NHS met the criteria for MCI (p = 0.001). The PD subjects showed a higher frequency of nonamnestic MCI (naMCI), compared to NHS (23.8 vs. 14.4%, p ≤ 0.0001). In comparison to NHS, PD was associated with a univariate OR of 1.9 (95% CI = 1.3–2.8) for naMCI, and this association was marginally significant after multiple comparisons (multivariate OR = 1.5, 95% CI = 0.96–2.3, p = 0.077). Conclusion: The association between PD and the impairment of nonmemory domains is probably due to frontal-subcortical involvement, which characterizes the disease.

© 2012 S. Karger AG, Basel


  

Author Contacts

Roberto Monastero, MD, PhD
LEPAD, Department of BioNeC
Università degli Studi di Palermo, Via La Loggia 1
IT–90129 Palermo (Italy)
Tel. +39 091 655 5185, E-Mail roberto.monastero@gmail.com

  

Article Information

Received: May 19, 2011
Accepted after revision: December 18, 2011
Published online: March 6, 2012
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 2, Number of References : 24

  

Publication Details

Neurodegenerative Diseases

Vol. 10, No. 1-4, Year 2012 (Cover Date: April 2012)

Journal Editor: Nitsch R.M. (Zürich), Hock C. (Zürich)
ISSN: 1660-2854 (Print), eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 5/19/2011 3:34:06 PM
Accepted: 12/18/2011
Published online: 3/6/2012
Issue release date: April 2012

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


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