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Vol. 67, No. 6, 2012
Issue release date: June 2012
Section title: Original Paper
Eur Neurol 2012;67:370–376
(DOI:10.1159/000336062)

Diffusion Tensor Imaging Shows Structural Remodeling of Stroke Mirror Region: Results from a Pilot Study

Granziera C. · Ay H. · Koniak S.P. · Krueger G. · Sorensen A.G.
aAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass., and bBoston University, Boston, Mass., USA; cDepartment of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, dSiemens Schweiz AG, Healthcare Sector IM&WS S, Renens, Switzerland, and eSiemens Healthcare North America

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/3/2011 9:33:41 AM
Accepted: 12/18/2011
Published online: 5/17/2012

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Background: The role of the non-injured hemisphere in stroke recovery is poorly understood. In this pilot study, we sought to explore the presence of structural changes detectable by diffusion tensor imaging (DTI) in the contralesional hemispheres of patients who recovered well from ischemic stroke. Methods: We analyzed serial DTI data from 16 stroke patients who had moderate initial neurological deficits (NIHSS scores 3–12) and good functional outcome at 3–6 months (NIHSS score 0 or modified Rankin Score ≤1). We segmented the brain tissue in gray and white matter (GM and WM) and measured the apparent diffusion coefficient (ADC) and fractional anisotropy in the infarct, in the contralesional infarct mirror region as well as in concentrically expanding regions around them. Results: We found that GM and WM ADC significantly increased in the infarct region (p < 0.01) from acute to chronic time points, whereas in the infarct mirror region, GM and WM ADC increased (p < 0.01) and WM fractional anisotropy decreased (p < 0.05). No significant changes were detected in other regions. Conclusion: DTI-based metrics are sensitive to regional structural changes in the contralesional hemisphere during stroke recovery. Prospective studies in larger cohorts with varying levels of recovery are needed to confirm our findings.


  

Author Contacts

Dr. Cristina Granziera
Department of Clinical Neurosciences
Centre Hospitalier Universitaire Vaudois
CH–1011 Lausanne (Switzerland)
Tel. +41 78 611 4349, E-Mail cristina.granziera@chuv.ch

  

Article Information

Received: October 3, 2011
Accepted: December 18, 2011
Published online: May 17, 2012
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 2, Number of References : 29

  

Publication Details

European Neurology

Vol. 67, No. 6, Year 2012 (Cover Date: June 2012)

Journal Editor: Bogousslavsky J. (Montreux)
ISSN: 0014-3022 (Print), eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/3/2011 9:33:41 AM
Accepted: 12/18/2011
Published online: 5/17/2012

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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