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Vol. 121, No. 2, 2012
Issue release date: April 2012
Section title: Original Research
Cardiology 2012;121:76–82
(DOI:10.1159/000336172)

Pulmonary Arterial Dilatation in Pulmonary Hypertension: Prevalence and Prognostic Relevance

Badagliacca R.a · Poscia R.a · Pezzuto B.a · Papa S.a · Nona A.a · Mancone M.a · Mezzapesa M.a · Nocioni M.a · Sciomer S.a · Valli G.b · Cedrone N.a · Fedele F.a · Vizza C.D.a
aDepartment of Cardiovascular and Respiratory Science, I School of Medicine and bDepartment of Clinical Medicine, University of Rome ‘Sapienza’ – Policlinico Umberto I, Rome, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 9/15/2011 9:09:08 AM
Accepted: 12/12/2011
Published online: 3/15/2012
Issue release date: April 2012

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 5

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Objectives: Pulmonary arterial dilatation is considered a consequence of chronic pulmonary hypertension (PH), but despite its relatively common detection, its prevalence and prognostic impact have not yet been systematically investigated. The aim of the study was to investigate these factors in a relatively large cohort of severe PH patients. Methods: One hundred and forty-one consecutive patients diagnosed with PH were monitored for a mean of 957 days. Data including functional class, exercise capacity, invasive hemodynamics and pulmonary artery (PA) echo/CT scan measurement were performed and outcomes prospectively collected. Results: PA dilatation is a common feature, present in the 76.6% of cases in this cohort of severe PH patients. Survival at 1, 2 and 3 years was 83, 71 and 58%, respectively. On univariate analysis, the baseline variables associated with a poor outcome were related to pulmonary arterial hypertension associated with connective tissue disease (CDT-PAH), New York Heart Association (NYHA) functional class, 6-min walk test and right atrial pressure. On multivariate analysis only CDT-PAH and NYHA functional class remained independently associated with poor survival. Conclusions: PA dilatation is commonly detected in severe PH patients and is not associated with an increased risk of death.

© 2012 S. Karger AG, Basel


  

Article Information

Received: September 15, 2011
Accepted after revision: December 12, 2011
Published online: March 15, 2012
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 5, Number of References : 24

  

Publication Details

Cardiology (International Journal of Cardiovascular Medicine, Surgery, Pathology and Pharmacology)

Vol. 121, No. 2, Year 2012 (Cover Date: April 2012)

Journal Editor: Borer J.S. (New York, N.Y.)
ISSN: 0008-6312 (Print), eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 9/15/2011 9:09:08 AM
Accepted: 12/12/2011
Published online: 3/15/2012
Issue release date: April 2012

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 5

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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