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Vol. 6, No. 1, 2012
Issue release date: January – April
Section title: Published: January 2012

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Case Rep Gastroenterol 2012;6:33–39
(DOI:10.1159/000336198)

Spindle and Giant Cell Type Undifferentiated Carcinoma of the Proximal Bile Duct

Ide T. · Miyoshi A. · Kitahara K. · Kai K. · Noshiro H.
Departments of aSurgery and bPathology and Microbiology, Saga University Faculty of Medicine, Saga, Japan

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Abstract

Undifferentiated spindle and giant cell carcinoma is an extremely rare malignant neoplasm arising in the extrahepatic bile duct. We herein present the case of a 67-year-old male who developed an undifferentiated spindle and giant cell carcinoma of the proximal bile duct. A nodular infiltrating tumor was located at the proximal bile duct, resulting in obstructive jaundice. Histologically, the tumor was composed of mainly spindle-shaped and giant cells and showed positive immunoreactivity for both cytokeratin and vimentin. Adjuvant chemotherapy was administered following extrahepatic bile duct resection, and he has been doing well for 16 months since the surgical treatment. The literature on this rare malignancy is also reviewed and discussed.


  

Author Contacts

Takao Ide
Department of Surgery, Saga University Faculty of Medicine
5-1-1 Nabeshima, Saga 849-8501 (Japan)
Tel. +81 952 342 349, E-Mail idetaka@cc.saga-u.ac.jp

  

Article Information

Published online: January 16, 2012
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 1,

  

Publication Details

Case Reports in Gastroenterology

Vol. 6, No. 1, Year 2012 (Cover Date: January - April)

Journal Editor: Urrutia R. (Rochester, Minn.), Lomberk G. (Rochester, Minn.)
ISSN: NIL (Print), eISSN: 1662-0631 (Online)

For additional information: http://www.karger.com/CRG


Article / Publication Details

First-Page Preview
Abstract of Published: January 2012

Published online: 1/16/2012

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: (Print)
eISSN: 1662-0631 (Online)

For additional information: http://www.karger.com/CRG


Open Access License / Drug Dosage

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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