A Case Report of T Cell Prolymphocytic Leukemia and Kaposi Sarcoma and a Review of T Cell Prolymphocytic LeukemiaPaul R.N. · Alizadeh L. · Ajayi O.I. · Karpurapu H. · Ganesan C. · Taddesse-Heath L. · Aggarwal A.
aDivision of Hematology/Oncology, Department of Medicine, and bDepartment of Pathology, Howard University Hospital, and cDivision of Hematology/Oncology, Department of Internal Medicine, Veterans Affairs Medical Center and George Washington University, Washington, D.C., USA
T cell prolymphocytic leukemia (T-PLL) is a rare mature T cell lymphoproliferative disease. It has been associated with an aggressive course, a poor response to conventional chemotherapy and a short median survival. Here we present a rare case of concurrent T-PLL and Kaposi sarcoma who achieved a complete hematologic and cytogenetic remission after a very short course of treatment with alemtuzumab. A review of T-PLL was done. In this review, clinical features, laboratory features and current therapeutic strategies of T-PLL are presented.
Rabindra N. Paul, MD
Division of Hematology/Oncology, Department of Medicine
Howard University Hospital, NW
Washington, DC 20060 (USA)
Received: July 5, 2011
Accepted after revision: December 28, 2011
Published online: April 13, 2012
Number of Print Pages : 9
Number of Figures : 3, Number of Tables : 0, Number of References : 62
Vol. 127, No. 4, Year 2012 (Cover Date: May 2012)
Journal Editor: Ben-Bassat I. (Qiryat-Ono)
ISSN: 0001-5792 (Print), eISSN: 1421-9662 (Online)
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