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Vol. 35, No. 3, 2012
Issue release date: March 2012
Section title: Original Report: Patient-Oriented, Translational Research
Am J Nephrol 2012;35:271–278
(DOI:10.1159/000336310)

Hydrocarbons and Kidney Damage: Potential Use of Neutrophil Gelatinase-Associated Lipocalin and Sister Chromatide Exchange

Lacquaniti A.a · Fenga C.b · Venuti V.A.b · Pernice L.b · Catanzariti S.b · Sirna G.c · Pernice F.c · Arena A.d · Lupica R.a · Abbate C.b · Buemi M.a
aSection of Nephrology, Department of Internal Medicine, bSection of Occupational Health, Department of Social and Environmental Medicine, cDepartment of Internal Medicine, and dDepartment of Surgical Science, Unit of Clinical Microbiology, Faculty of Medicine, University of Messina, Messina, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: 12/8/2011
Accepted: 1/7/2012
Published online: 2/25/2012
Issue release date: March 2012

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 2

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background: Millions of workers are exposed to polycyclic aromatic hydrocarbons (PAHs) and it is known that the kidney is a target for toxic chemicals. We have evaluated neutrophil gelatinase-associated lipocalin (NGAL) as a potential marker of tubular damage and have used it, with sister chromatid exchange (SCE) analysis, to evaluate carcinogenic risk in a group of workers from an oil refinery. Methods: NGAL and SCE analysis were evaluated in 160 subjects. Exposed subjects were divided into three groups, according to levels of exposure to PAHs: 40 highly exposed workmen (WM), 40 less exposed office workers (OW), and 40 subjects (GE) living in Gela. The control group included 40 healthy subjects (HS). Results: WM, OW and GE showed higher NGAL levels than HS. WM had higher levels of NGAL than the OW and GE groups; in ROC analysis, serum NGAL showed a good diagnostic profile (sensitivity 87.5%; specificity 100.0%), as did urinary NGAL (sensitivity 90.0%; specificity 92.5%). Moreover, regarding SCE analysis, WM showed higher values than HS. A direct correlation between SCE and serum NGAL was found in WM, the group most exposed to PAHs. Conclusion: The high values of NGAL are an expression of damage to the renal tubule determined by exposure to PAHs. Compared to the other groups studied, chromosomal aberrations – expressed as SCE – were increased in WM, the group most exposed to PAHs, indicating genotoxic damage. NGAL may also play a role in the process of carcinogenesis having a direct correlation with the number of SCEs.

© 2012 S. Karger AG, Basel


  

Author Contacts

Prof. Michele Buemi
Via Salita Villa Contino 30
IT–98100 Messina (Italy)
Tel. +39 090 221 2396
E-Mail buemim@unime.it

  

Article Information

Received: December 8, 2011
Accepted: January 7, 2012
Published online: February 25, 2012
Number of Print Pages : 8
Number of Figures : 6, Number of Tables : 2, Number of References : 27

  

Publication Details

American Journal of Nephrology

Vol. 35, No. 3, Year 2012 (Cover Date: March 2012)

Journal Editor: Bakris G. (Chicago, Ill.)
ISSN: 0250-8095 (Print), eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: 12/8/2011
Accepted: 1/7/2012
Published online: 2/25/2012
Issue release date: March 2012

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 2

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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