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Table of Contents
Vol. 82, No. 3, 2012
Issue release date: April 2012
Section title: Clinical Study
Oncology 2012;82:131–138
(DOI:10.1159/000336480)

Subjective and Objective Assessment of Edema during Adjuvant Chemotherapy for Breast Cancer Using Taxane-Containing Regimens in a Randomized Controlled Trial: The National Surgical Adjuvant Study of Breast Cancer 02

Ohsumi S.a · Shimozuma K.b · Ohashi Y.c · Takeuchi A.c · Suemasu K.d · Kuranami M.e · Ohno S.f · Watanabe T.g
aDepartment of Breast Oncology, NHO Shikoku Cancer Center, Matsuyama, bDepartment of Biomedical Sciences, College of Life Science, Ritsumeikan University, Kusatsu, cDepartment of Biostatistics, School of Public Health, University of Tokyo, Tokyo, dArche Clinic, Saitama, eDepartment of Surgery, Kitasato University School of Medicine, Sagamihara, fDepartment of Breast Oncology, NHO Kyushu Cancer Center, Fukuoka, and gHamamatsu Oncology Center, Hamamatsu, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: October 30, 2011
Accepted: January 03, 2012
Published online: March 15, 2012
Issue release date: April 2012

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objective: To elucidate the time course of taxane-induced edema which may affect the patients’ quality of life (QOL). Patients and Methods: Our study included the first 300 Japanese patients assigned to 1 of 4 regimens using docetaxel (DTX) or paclitaxel (PTX) by 1:1:1:1 in a randomized controlled trial to evaluate the efficacy of adjuvant therapies for node-positive breast cancer. Patients’ QOL was prospectively assessed by the Functional Assessment of Cancer Therapy (FACT)-breast and -taxane (FACT-T) subscale. The scores of FACT items regarding edema and body weight were used as indicators of edema. Results: The scores for ‘anasarca’, ‘edema of the hands’ and ‘edema of the legs and feet’ of the FACT-T subscale worsened up to 1–2 months after chemotherapy, and body weights increased remarkably until cycle 8 in patients treated with DTX alone (75 mg/m2, 8 cycles, every 3 weeks). Edema-related symptoms and body weight were relatively stable in the other treatment groups. There were statistically significant differences in the scores of those items and in the changes of body weight both between the DTX-alone group and the other three groups combined, and between the groups using DTX and those using PTX. Conclusion: Many patients receiving DTX for >4 cycles suffered significantly from edema.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: October 30, 2011
Accepted: January 03, 2012
Published online: March 15, 2012
Issue release date: April 2012

Number of Print Pages: 8
Number of Figures: 6
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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