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Vol. 82, No. 3, 2012
Issue release date: April 2012
Section title: Clinical Study
Oncology 2012;82:139–146
(DOI:10.1159/000336490)

Sequential Local Injection of Low-Dose Interferon-Beta for Maintenance Therapy in Stage II and III Melanoma: A Single-Institution Matched Case-Control Study

Aoyagi S. · Hata H. · Homma E. · Shimizu H.
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 12/8/2011 8:36:45 PM
Accepted: 1/4/2012
Published online: 3/15/2012

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objective: To determine the beneficial effect of maintenance therapy in stage II and III melanoma by sequential local injection of low-dose interferon-β. Methods: We reviewed 46 patients with stage II and III primary melanoma at our institution from 2004 through 2009. Twenty-one patients were treated with interferon-β maintenance therapy consisting of subcutaneous injection of natural interferon-β at a dose of 3 × 106 IU/day for 10 consecutive days, and 25 patients underwent observation alone. Results: Compared with all patients, overall survival and relapse-free survival were significantly worse in the observation group than in the interferon-β group (p = 0.024 and 0.029, respectively). In stage II, a significant difference in overall survival, but not in relapse-free survival, was seen between the two groups (p = 0.041). When the interferon-β group was stratified by subgroup, there was a statistical difference only between dosage and duration (p = 0.027 and p < 0.001, respectively). Conclusions: This study demonstrates that maintenance therapy by interferon-β is beneficial in the outcome of the disease without substantial toxic effects, especially in patients with stage II melanoma. Extension of the duration of treatment beyond 2 years could further improve the therapeutic efficacy of interferon-β.


  

Author Contacts

Satoru Aoyagi, MD, PhD
Department of Dermatology
Hokkaido University Graduate School of Medicine
N15 W7, Kita-ku, Sapporo 060-8638 (Japan)
Tel. +81 11 706 7387, E-Mail saoyagi@med.hokudai.ac.jp

  

Article Information

Received: December 8, 2011
Accepted after revision: January 4, 2012
Published online: March 15, 2012
Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 2, Number of References : 26
Additional supplementary material is available online - Number of Parts : 1

  

Publication Details

Oncology (International Journal for Cancer Research and Treatment)

Vol. 82, No. 3, Year 2012 (Cover Date: April 2012)

Journal Editor: Markman M. (Philadelphia, Pa.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 12/8/2011 8:36:45 PM
Accepted: 1/4/2012
Published online: 3/15/2012

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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