Associations between Polymorphisms in Genes Involved in Fatty Acid Metabolism and Dietary Fat IntakesBouchard-Mercier A. · Paradis A.-M. · Pérusse L. · Vohl M.-C.
aInstitute of Nutraceuticals and Functional Foods (INAF), bDepartment of Food Science and Nutrition, and cDivision of Kinesiology, Department of Social and Preventive Medicine, Laval University, Quebec, Que., Canada
Background: Obesity prevalence is growing in our population. Twin studies have estimated the heritability of dietary intakes to about 30%. The objective of this study was to verify whether polymorphisms in genes involved in fatty acid metabolism are associated with dietary fat intakes. Methods: Seven hundred participants were recruited. A validated food frequency questionnaire was used to assess dietary intakes. PCR-RFLP and TAQMAN methodology were used to genotype PPARα Leu162Val, PPARγ Pro12Ala, PPARδ –87T>C, PPARGC1α Gly482Ser, FASN Val1483Ile and SREBF1 c.*619C>G. Statistical analyses were executed with SAS statistical package. Results: Carriers of the Ala12 allele of PPARγ Pro12Ala polymorphism had higher intakes of total fat (p = 0.04). For FASN Val1483Ile polymorphism, significant gene-sex interaction effects were found for total fat and saturated fat intakes (p = 0.02 and p = 0.002, respectively). No significant difference in fat intakes was observed for PPARα Leu162Val, PPARδ –87T>C, PPARGC1α Gly482Ser and SREBF1 c.*619C>G polymorphisms. Conclusions: Polymorphisms in PPARγ and FASN seem to be associated with dietary fat intakes. Genetic variants are important to take into account when studying dietary intakes.
Marie-Claude Vohl, PhD
Institute of Nutraceuticals and Functional Foods (INAF)
2440 Hochelaga Blvd.
Quebec, QC G1K 7P4 (Canada)
Tel. +1 418 656 2131, ext. 4676, E-Mail email@example.com
Received: September 13, 2011
Accepted: January 16, 2012
Published online: March 8, 2012
Number of Print Pages : 12
Number of Figures : 0, Number of Tables : 4, Number of References : 82
Journal of Nutrigenetics and Nutrigenomics
Vol. 5, No. 1, Year 2012 (Cover Date: June 2012)
Journal Editor: Pérusse L. (Quebec, Que.)
ISSN: 1661-6499 (Print), eISSN: 1661-6758 (Online)
For additional information: http://www.karger.com/JNN