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7, No. 1, 2012
Issue release date: February 2012
Section title: Original Article · Originalarbeit
Free Access
Breast Care 2012;7:13–17
(DOI:10.1159/000336539)

Analysis of Clinical Features and Outcome of 356 Triple-Negative Breast Cancer Patients in China

Zhang L. · Hao C. · Dong G. · Tong Z.
Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Cancer Research Key Laboratory of Education Ministry, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin, China

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Abstract

Background: The purpose of this study was to investigate the clinicopathological features and analyze the prognostic factors of triple-negative breast cancer (TNBC). Patients and Methods: The clinical data of 1,788 breast cancer patients was collected and analyzed. The Kaplan-Meier method was used to estimate survival. Multivariate analysis of the prognostic factors for survival was performed using the Cox regression model. Results: Patients with TNBC exhibited characteristics significantly differing from those with non-TNBC. There was a higher proportion of patients with age < 35 years, stage III disease, tumor size > 5 cm, lymph node positivity, and histological grade 3. The 5-year disease-free survival (DFS) rates of TNBC and non-TNBC patients were 75.7 and 79.6%, respectively (p < 0.05). 5-year overall survival (OS) was 86.6 and 93.5%, respectively (p < 0.05). In multivariate Cox regression analysis, the independent prognostic factors for shorter DFS were age < 35 years (hazard ratio (HR) 2.105), positive lymph nodes (HR 7.039), histological grade 3 (HR 1.841), and for shorter OS positive lymph nodes (HR 4.626). Conclusion: The proportion of TNBC in breast cancer in China is higher than in other areas. TNBC is correlated with younger age, larger tumor size, positive lymph nodes, higher clinical stage and histological grade, and lower DFS and OS, which is consistent with previous reports.


  

Author Contacts

Zhongsheng Tong, MD, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China, Tel. +86 2223-340123/-2002, Fax -511809, tonghang@medmail.com.cn

  

Article Information

Published online: February 13, 2012
Number of Print Pages : 5

  

Publication Details

Breast Care (Multidisciplinary Journal for Research, Diagnosis and Therapy)

Vol. 7, No. 1, Year 2012 (Cover Date: February 2012)

Journal Editor: Harbeck N. (Köln), Thomssen C. (Halle/Saale), Gnant M. (Wien)
ISSN: 1661-3791 (Print), eISSN: 1661-3805 (Online)

For additional information: http://www.karger.com/BRC


Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: 2/13/2012
Issue release date: February 2012

Number of Print Pages: 0
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-3791 (Print)
eISSN: 1661-3805 (Online)

For additional information: http://www.karger.com/BRC


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