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Table of Contents
Vol. 33, No. 1, 2012
Issue release date: March 2012
Section title: Original Research Article
Dement Geriatr Cogn Disord 2012;33:59–72
(DOI:10.1159/000336598)

Clock Test Deficits Related to the Global Cognitive State in Alzheimer’s and Parkinson’s Disease

Saur R.a · Maier C.a · Milian M.a, b · Riedel E.c · Berg D.c, d · Liepelt-Scarfone I.c, d · Leyhe T.a, e
Departments of aPsychiatry and Psychotherapy, and bNeurosurgery, University of Tübingen, cHertie Institute for Clinical Brain Research, Center of Neurology, dGerman Center for Neurodegenerative Diseases, University of Tübingen, and eGeriatric Center, University Hospital of Tübingen, Tübingen, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: December 23, 2011
Published online: March 08, 2012
Issue release date: March 2012

Number of Print Pages: 14
Number of Figures: 5
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background/Aims: Clock drawing (CD) seems to be impaired quite early in the process of cognitive decline in Parkinson’s disease (PD). Methods: We assessed performance on the CD test (CDT), clock setting test (CST) and clock reading test (CRT) in 32 elderly healthy controls, 41 patients with PD, 23 patients with amnestic mild cognitive impairment (aMCI) and 40 patients with Alzheimer’s dementia (AD). Our focus was on comparing the performance of PD and aMCI/AD patients in relation to their global cognitive states (operationalized by the Mini Mental Status Examination). We also analyzed qualitative differences in errors of drawing, setting and reading clocks. Results: We found that performance in CDT, but not in the CST or CRT, was impaired earlier in PD than in aMCI/AD. Incorrect placement of the minute hand was the most prominent error in both patient groups. We found no specific influence of visuospatial dysfunction in PD on clock drawing. Conclusion: Our findings suggest that executive function related to retrieval of semantic memory about the minute hand is compromised early in PD.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: December 23, 2011
Published online: March 08, 2012
Issue release date: March 2012

Number of Print Pages: 14
Number of Figures: 5
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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