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Vol. 30, No. 2, 2012
Issue release date: June 2012
Section title: Paper
Dig Dis 2012;30:212–215
(DOI:10.1159/000336704)

Diagnosis and Treatment of Autoimmune Hepatitis

Lata J.
Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/20/2012
Issue release date: June 2012

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: http://www.karger.com/DDI

Abstract

Autoimmune hepatitis (AIH) is a generally progressive, chronic liver disease of unknown etiology, relatively uncommon, associated with chronic hepatic inflammation. An environmental agent is hypothesized to trigger an immune-mediated attack directed against liver antigens in genetically predisposed individuals. The disease can lead to potentially fatal liver dysfunction. AIH is characterized by female predominance (sex ratio 3.6:1), hypergammaglobulinemia, circulating autoantibodies and association with human leukocyte antigens DR3 or DR4. The diagnosis of AIH is based on the revised descriptive criteria reported by the International Autoimmune Hepatitis Group in 1999. Without appropriate immunosuppressive therapy AIH has a very poor prognosis with 10-year survival rates as low as 10%, but usually very good response to immunosuppression, and survival rates of responders to the treatment are similar to those of healthy counterparts from the same population.

© 2012 S. Karger AG, Basel


  

Author Contacts

Prof. Jan Lata
Dlouhe hony 10
CZ–62100 Brno (Czech Republic)
Tel. +420 77 757 0950
E-Mail jan.lata@osu.cz

  

Article Information

Published online: June 20, 2012
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 0, Number of References : 12

  

Publication Details

Digestive Diseases (Clinical Reviews)

Vol. 30, No. 2, Year 2012 (Cover Date: June 2012)

Journal Editor: Malfertheiner P. (Magdeburg)
ISSN: 0257-2753 (Print), eISSN: 1421-9875 (Online)

For additional information: http://www.karger.com/DDI


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/20/2012
Issue release date: June 2012

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: http://www.karger.com/DDI


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