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Table of Contents
Vol. 121, No. 3, 2012
Issue release date: May 2012
Section title: Original Research
Cardiology 2012;121:186–193
(DOI:10.1159/000336810)

Outcomes of Cardiac Involvement in Patients with Late-Stage Duchenne Muscular Dystrophy under Management in the Pulmonary Rehabilitation Center of a Tertiary Referral Hospital

Kwon S.W.a · Kang S.-W.b · Kim J.-Y.c · Choi E.-Y.c · Yoon Y.W.c · Park Y.M.c · Ma D.W.c · Chung H.c · Kwon H.M.c · Rim S.-J.c
aDivision of Cardiology, Department of Internal Medicine, Yongin Severance Hospital, bDepartment of Physical Medicine and Rehabilitation and cDivision of Cardiology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 6/28/2011 5:52:02 AM
Accepted: 1/10/2012
Published online: 4/12/2012
Issue release date: May 2012

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD

Abstract

Objectives: The purpose of this study was to investigate the clinical outcome as well as the sequential changes of cardiac function in late-stage Duchenne muscular dystrophy (DMD) patients by 2-dimensional echocardiography. Methods: A total of 31 individuals (initial age: 21.6 ± 5.0 years, range: 15–35 years) with late-stage DMD (Swinyard-Deaver’s stage 7 or 8) were enrolled. All of these patients had respiratory insufficiency and were on ventilator support. Sequential echocardiographic data were collected over at least 3 years. Repeated measures analysis of variance was used to compare changes in left ventricular ejection fraction (LVEF) over time. Results: The sequential change in the mean LVEF showed no significant differences with initial, 1-, 2-, and 3-year follow-up LVEFs which were 42.2, 42.9, 43.8 and 42.6%, respectively (p = 0.320). In terms of the clinical outcome, all but 1 patient survived during the follow-up period of 46.5 ± 9.1 months. Conclusions: The cardiac function in late-stage DMD patients showed a stabilization of LVEF on adequate ventilatory support and optimal cardiac medication therapy until their mid-30s. In addition, considering the favorable clinical outcome in our study, the process of cardiac involvement in late-stage DMD may demonstrate that in some patients it is nonprogressive.

© 2012 S. Karger AG, Basel


  

Author Contacts

Prof. Se-Joong Rim, MD, PhD
Division of Cardiology, Department of Internal Medicine
Gangnam Severance Hospital, Yonsei University College of Medicine
712 Eonjuro, Gangnam-gu, Seoul 135-270 (Republic of Korea)
Tel. +82 2 2019 3310, E-Mail sejoong@yuhs.ac

  

Article Information

Received: June 28, 2011
Accepted after revision: January 10, 2012
Published online: April 12, 2012
Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 2, Number of References : 24

  

Publication Details

Cardiology (International Journal of Cardiovascular Medicine, Surgery, Pathology and Pharmacology)

Vol. 121, No. 3, Year 2012 (Cover Date: May 2012)

Journal Editor: Borer J.S. (New York, N.Y.)
ISSN: 0008-6312 (Print), eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: 6/28/2011 5:52:02 AM
Accepted: 1/10/2012
Published online: 4/12/2012
Issue release date: May 2012

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: http://www.karger.com/CRD


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