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Vol. 77, No. 2, 2012
Issue release date: April 2012
Section title: Original Paper
Horm Res Paediatr 2012;77:121–126
(DOI:10.1159/000336923)

Gastric Autoimmunity in Children and Adolescents with Type 1 Diabetes: A Prospective Study

Kakleas K. · Kostaki M. · Critselis E. · Karayianni C. · Giannaki M. · Anyfantakis K. · Haramaras I. · Fotinou A. · Papathanasiou A. · Karavanaki K.
aDiabetic Clinic, Second University Department of Pediatrics, ‘P. & A. Kyriakou’ Children’s Hospital, National and Kapodistrian University of Athens School of Medicine, bGastroenterology Clinic, Second University Department of Pediatrics, ‘P. & A. Kyriakou’ Children’s Hospital, cDepartment of Pediatric Endocrinology and dHormone Laboratory, ‘P. & A. Kyriakou’ Children’s Hospital, and eMicrobiology Department, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/21/2011
Accepted: 1/30/2012
Published online: 3/15/2012

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Background/Aims: Type 1 diabetes (T1DM) is associated with gastric autoimmunity, which is characterized by the presence of parietal cell antibodies (APCA). We investigated gastric autoimmunity prevalence in T1DM children, its manifestations, determinants and association with thyroid gland (anti-Tg, anti-TPO) and pancreatic β-cell autoimmunity (anti-GAD) at baseline and 4 years later. Methods: The initial cohort (D1) included 97 children with T1DM. At follow-up after 4 years (D2), 84.5% of participants were evaluated. We assessed APCA, anti-Tg, anti-TPO, and anti-GAD presence, as well as symptoms of gastritis. APCA-positive patients were evaluated with gastrin, B12, ferritin levels and were submitted to gastroscopy. Results: Thyroid antibody positivity was increased among the APCA-positive patients. Four years later, among initially APCA-positive patients, 2/6 became APCA negative, while 4/6 developed high titers of APCA. On gastroscopy, 2 patients had chronic hypertrophic gastritis and one Helicobacter pylori gastritis. Conclusions: Gastric autoimmunity was associated with thyroid autoimmunity and anti-GAD persistence. After 4 years, the majority of APCA-positive patients developed high titers of APCA and mild symptoms of gastritis. Thus, patients with T1DM, and in particular those with thyroid and/or pancreatic autoimmunity, should have periodic autoantibody screening for the early diagnosis and follow-up of gastric autoimmunity.


  

Author Contacts

Kyriaki Karavanaki, MD, PhD
Second University Department of Pediatrics
‘P. & A. Kyriakou’ Children’s Hospital Goudi
GR–11527 Athens (Greece)
Tel. +30 210 77 26 488, E-Mail kkarav@yahoo.gr

  

Article Information

Received: July 21, 2011
Accepted: January 30, 2012
Published online: March 16, 2012
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 3, Number of References : 31

  

Publication Details

Hormone Research in Paediatrics (From Developmental Endocrinology to Clinical Research)

Vol. 77, No. 2, Year 2012 (Cover Date: April 2012)

Journal Editor: Czernichow P. (Paris)
ISSN: 1663-2818 (Print), eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/21/2011
Accepted: 1/30/2012
Published online: 3/15/2012

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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