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Table of Contents
Vol. 128, No. 1, 2012
Issue release date: June 2012
Section title: Original Paper
Acta Haematol 2012;128:7–16
(DOI:10.1159/000337039)

Early Recovery of Immunity after Cord-Blood Transplantation in Children: Qualitative Features and Impact of Cytomegalovirus Infection

Farnault L.b · Chambost H.a · Zandotti C.c · Mallet F.b · Barlogis V.a · Galambrun C.a · Michel G.a · Olive D.b
aDepartment of Pediatric Hematology, Hôpital de la Timone Enfants, bINSERM UMR 891, Institut Paoli Calmettes, Université de la Méditerranée, IBiSA Cancer Immunomonitoring Platform, IFR 137, and cFédération de Microbiologie, Assistance Publique-Hôpitaux de Marseille, Marseille, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 29, 2011
Accepted: February 01, 2012
Published online: May 03, 2012
Issue release date: June 2012

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

This study investigated immune recovery and the effect of cytomegalovirus (CMV) infection on the early stages of T-lymphocyte recovery after cord-blood transplantation (CBT) from unrelated donors to 24 children. In addition, 15 children who were recipients of a bone-marrow transplant (BMT) were studied concomitantly. The main objectives of the study were whether lymphocytes from CBT recipients were capable of rapid qualitative differentiation in the effector memory (EM) stage, of regenerating de novo naïve cells and of responding to CMV infection. Results showed that CB lymphocytes were mainly differentiated into the EM stage at 3 months and into the naïve stage at 6 months. CMV infection induced a dramatic increase in CD8 but not CD4 T-cell counts, and differentiation into the EM stage with high perforin contents. Our data suggest that CB lymphocytes are capable of rapid differentiation in children, but stabilization of lymphocyte counts in children is associated with effective naïve subset regeneration at 6 months. Moreover, the T-cell repertoire is capable of rapid adjustment when CMV infection occurs.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 29, 2011
Accepted: February 01, 2012
Published online: May 03, 2012
Issue release date: June 2012

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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