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Vol. 227, Suppl. 1, 2012
Issue release date: April 2012
Section title: Anti-VEGF Treatment in DME
Ophthalmologica 2012;227(suppl 1):21–29
(DOI:10.1159/000337156)

Diabetic Macular Edema

Lang G.E.
University Eye Hospital Ulm, Ulm, Germany

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Article / Publication Details

First-Page Preview
Abstract of Anti-VEGF Treatment in DME

Published online: 4/24/2012
Issue release date: April 2012

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 0

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH

Abstract

Diabetic retinopathy is one of the major complications of diabetes mellitus and a leading cause of visual loss. Diabetic macular edema (DME) is an ocular manifestation of the disease causing visual deterioration. The prevalence of visual impairment due to DME is estimated to be 5.4% in Europe. Vascular endothelial growth factor (VEGF) is overexpressed in diabetic eyes and plays a key role in the development of DME. VEGF levels were proven to be elevated in the vitreous and retina in patients with diabetic retinopathy. VEGF causes a breakdown of the blood-retinal barrier by influencing the tight junctions of retinal endothelial cells and leading to accumulation of fluid in the macula. Therefore, intravitreal VEGF inhibitors are ideal candidates to treat DME by counteracting VEGF overexpression. This review summarizes the results of the most recent prospective, controlled studies on DME with promising novel VEGF inhibitors. It focuses on the efficacy and safety aspects of anti-VEGF treatment of DME.

© 2012 S. Karger AG, Basel


  

Article Information

Published online: April 24, 2012
Number of Print Pages : 9
Number of Figures : 4, Number of Tables : 0, Number of References : 18

  

Publication Details

Ophthalmologica (The Journal of the European Society of Retina Specialists)

Vol. 227, No. Suppl. 1, Year 2012 (Cover Date: April 2012)

Journal Editor: Cunha-Vaz J. (Coimbra)
ISSN: 0030-3755 (Print), eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


Article / Publication Details

First-Page Preview
Abstract of Anti-VEGF Treatment in DME

Published online: 4/24/2012
Issue release date: April 2012

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 0

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


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