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Vol. 83, No. 1, 2012
Issue release date: July 2012
Section title: Clinical Study
Oncology 2012;83:16–23
(DOI:10.1159/000337574)

Usefulness of the Preoperative Administration of Tegafur Suppositories as Alternative Adjuvant Chemotherapy for Patients with Resectable Stage II or III Colorectal Cancer: A KODK4 Multicenter Randomized Control Trial

Okabayashi K.a · Hasegawa H.a · Watanabe M.c · Ohishi T.b · Hisa A.d · Kitagawa Y.a
aDepartment of Surgery, Keio University, School of Medicine, and bDepartment of Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, cDepartment of Surgery, Kitasato University, Sagamihara, and dDepartment of Surgery, Saitama Social Insurance Hospital, Saitama, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 12/5/2011
Accepted: 2/20/2012
Published online: 6/21/2012
Issue release date: July 2012

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objective: The aim of this study was to evaluate the feasibility and conferred protection against recurrence of preoperatively administered tegafur suppositories following the intravenous and oral administration of fluoropyrimidine in a multicenter randomized control trial. Methods: Patients with clinical T3/4 colorectal cancer were randomly assigned to receive the preoperative administration of tegafur suppositories (group A) or no preoperative treatment (group B). The primary end points were disease-free survival (DFS) and overall survival (OS). Results: The mean follow-up periods were 80.9 ± 31.0 months in group A and 64.5 ± 28.8 months in group B. The 5-year DFS rates were 89.3% in group A and 70.3% in group B (p = 0.045), whereas the 5-year OS rates were 91.4% in group A and 73.2% in group B (p = 0.051). Furthermore, a significant difference in the cumulative distant metastatic rate was observed (group A, 7.4% vs. group B, 23.4%; p = 0.03). However, no significant difference in the cumulative local recurrence rate was seen (group A, 4.6% vs. group B, 8.2%; p = 0.68). Conclusion: Despite a relatively small sample size, preoperative tegafur suppositories might protect recurrences and improve survival rates, mainly by preventing distant metastasis. These findings suggest the utility of tegafur suppositories as an alternative neoadjuvant treatment in modern chemotherapy for colorectal cancer.

© 2012 S. Karger AG, Basel


  

Author Contacts

H. Hasegawa
Department of Surgery, Keio University, School of Medicine
35 Shinanomachi, Shinjuku-ku
Tokyo 160-8582 (Japan)
Tel. +81 3 3353 1211, E-Mail hasegawa@z8.keio.jp

  

Article Information

Received: December 5, 2011
Accepted after revision: February 20, 2012
Published online: June 21, 2012
Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 2, Number of References : 22
Additional supplementary material is available online - Number of Parts : 1

  

Publication Details

Oncology (International Journal for Cancer Research and Treatment)

Vol. 83, No. 1, Year 2012 (Cover Date: July 2012)

Journal Editor: Markman M. (Philadelphia, Pa.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 12/5/2011
Accepted: 2/20/2012
Published online: 6/21/2012
Issue release date: July 2012

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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