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29, No. 1-2, 2012
Issue release date: February 2012
Section title: Original
Cell Physiol Biochem 2012;29:261–268

The Effects of 17β-estradiol on Mitochondrial Biogenesis and Function in Breast Cancer Cell Lines are Dependent on the ERα/ERβ Ratio

Sastre-Serra J.1,2 · Nadal-Serrano M.1,2 · Pons D.G.1,2 · Valle A.1,2 · Oliver J.1,2 · Roca P.1,2
1Grupo multidisciplinar de Oncología Traslacional, Institut Universitari d′Investigació en Ciències de la Salut (IUNICS), Palma de Mallorca, Illes Balears,2Ciber Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III

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Background/Aims: 17β-estradiol (E2) is a risk factor for the development of breast cancer, and cause tumorigenesis in epithelial breast cells. Moreover, E2 has distinct effects on different tissues that are attributed to the presence of two estrogen receptor isoforms, ERα and ERβ. Methods: The effect of E2 on mitochondrial biogenesis and function was investigated in two breast cancer cell lines with different estrogen receptor ratios, MCF-7 (high ERα/ERβ ratio) and T47D (low ERα/ERβ ratio) cell lines treated with physiological concentrations of E2 (1 nM). Results: Mitochondria of the MCF-7 cell line showed an increase in proliferation but a decrease in functionality, while the T47D cell line, with low ERα/ERβ ratio, maintained functionality with fewer mitochondria. Conclusion: Our results suggest that ERs endowment and its subtypes relation have an effect on treatment response and could contribute new ideas about mitochondria and ERs in breast cancer, as well as new indicators to the disease progression.

© 2012 S. Karger AG, Basel


Author Contacts

Pilar Roca
Universitat de les Illes Balears
Dept. Biologia Fonamental i Ciè ncies de la Salut
Ctra. Valldemossa Km 7,5. E07122 Palma de Mallorca, Illes Balears (Spain)
Fax +34 971 173184, E-Mail


Article Information

Accepted: December 12, 2011
Published online: March 01, 2012
Number of Print Pages : 8


Publication Details

Cellular Physiology and Biochemistry (International Journal of Experimental Cellular Physiology, Biochemistry andPharmacology)

Vol. 29, No. 1-2, Year 2012 (Cover Date: February 2012)

Journal Editor: F. Lang, Tübingen
ISSN: 1015–8987 (Print), eISSN: 1421–9778 (Online)

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Article / Publication Details

First-Page Preview
Abstract of Original

Accepted: 12/12/2011
Published online: 3/1/2012
Issue release date: February 2012

Number of Print Pages: 0
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-8987 (Print)
eISSN: 1421-9778 (Online)

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Copyright / Drug Dosage

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