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Cover

Cleft Lip and Palate

Epidemiology, Aetiology and Treatment

Editor(s): Cobourne M.T. (London) 
Table of Contents
Vol. 16, 2012
Section title: Paper
Cobourne MT (ed): Cleft Lip and Palate. Epidemiology, Aetiology and Treatment. Front Oral Biol. Basel, Karger, 2012, vol 16, pp 147–154
(DOI:10.1159/000337667)

Future Directions: Molecular Approaches Provide Insights into Palatal Clefting and Repair

Liu K.J.
Department of Craniofacial Development and Stem Cell Biology, Guy’s Hospital, King’s College London, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: June 25, 2012
Cover Date: 2012

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-318-02107-3 (Print)
eISBN: 978-3-318-02108-0 (Online)

Abstract

Normal development of the palate depends on spatial and temporal coordination of complex cellular processes and tissue-tissue interactions. Because these processes are quite sensitive to environmental and genetic perturbation, clefts of the palate are among the most common congenital anomalies seen in live births. The clinical burden of cleft palate is significant, as conventional treatments include surgical repair combined with long-term rehabilitation. Affected children may require multiple operations and often have secondary problems such as perturbed speech development, dental occlusion, maxillary growth deficiencies and otitis media. Recent reports, from patient studies and mouse models, have implicated a number of genes in palatogenesis. It is difficult to pinpoint the direct pathological effects of specific genes in humans; therefore, the majority of mechanistic insights have derived from murine models. Furthermore, recent technological advances have made mice an ideal system for studying the signalling events associated with cleft palate. This review discusses several illustrative examples of genetic or molecular studies in which in utero reversal of cleft palate reveals sequential requirements in palate formation. As we develop a more comprehensive understanding of the genetic mechanisms underlying normal and pathological palate development, we can begin to consider the possibility of molecular tools to complement or even replace surgical interventions.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: June 25, 2012
Cover Date: 2012

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-318-02107-3 (Print)
eISBN: 978-3-318-02108-0 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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