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Vol. 4, No. 1, 2012
Issue release date: January – April
Section title: Published: March 2012

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Case Rep Dermatol 2012;4:85–91
(DOI:10.1159/000337751)

A Case of Generalized Acanthosis Nigricans with Positive Lupus Erythematosus-Related Autoantibodies and Antimicrosomal Antibody: Autoimmune Acanthosis Nigricans

Kondo Y.a · Umegaki N.a · Terao M.a · Murota H.a · Kimura T.b · Katayama I.a
aDepartment of Dermatology Integrated Medicine, Osaka University Graduate School of Medicine, and bDepartment of Internal Medicine, Suita Municipal Hospital, Suita-City, Japan

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Abstract

Acanthosis nigricans (AN) is a hyperpigmented keratotic skin lesion known to be associated with malignant disease and endocrinopathy. We report a very rare case of generalized AN with Sjögren’s syndrome- and systemic lupus erythematosus-like features but without type B insulin resistance. Neither internal malignancy nor other endocrinological disorders, including glucose intolerance, were detected during a 10-year clinical course with benign diffuse papillomatosis extending from the mucosa of the larynx to the esophagogastric junction. The case was complicated with chronic thyroiditis and interstitial pneumonia, which were not treated with any medication. AN skin lesions and mucosal papillomatosis regressed with oral cyclosporine A, accompanied by the lowering of autoantibody titers. This is the first report of generalized AN involving an area from the mucosa of the larynx to the esophagogastric junction accompanied by autoimmune manifestations which responded to systemic immunosuppressive therapy.

© 2012 S. Karger AG, Basel


  

Author Contacts

Ichiro Katayama
Department of Dermatology Integrated Medicine
Osaka University Graduate School of Medicine
2-2, Yamadaoka, Suita-City 565-0871 (Japan)
Tel. +81 6 6879 3031, E-Mail katayama@derma.med.osaka-u.ac.jp

  

Article Information

Published online: March 30, 2012
Number of Print Pages : 7
Number of Figures : 3,

  

Publication Details

Case Reports in Dermatology

Vol. 4, No. 1, Year 2012 (Cover Date: January - April)

Journal Editor: Jemec G.B.E. (Roskilde)
ISSN: 1662-6567 (Print), eISSN: 1662-6567 (Online)

For additional information: http://www.karger.com/CDE


Article / Publication Details

First-Page Preview
Abstract of Published: March 2012

Published online: 3/30/2012
Issue release date: January – April

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: (Print)
eISSN: 1662-6567 (Online)

For additional information: http://www.karger.com/CDE


Open Access License / Drug Dosage

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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