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Vol. 32, No. 3, 2012
Issue release date: November 2012
Section title: Original Paper
Fetal Diagn Ther 2012;32:201–208
(DOI:10.1159/000338133)

Single Umbilical Artery: Does Side Matter?

Santillan M. · Santillan D. · Fleener D. · Stegmann B. · Zamba G. · Hunter S. · Yankowitz J.
aDepartment of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, University of Iowa Hospitals and Clinics, bDepartment of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, and cDepartment of Obstetrics and Gynecology, University of South Florida, Tampa, Fla., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/4/2011 11:31:55 AM
Accepted: 3/12/2012
Published online: 6/1/2012

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 6

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

Introduction: The aim of this study was to determine if laterality of an absent umbilical artery (AUA) is associated with specific sonographic findings, chromosomal defects or postpartum birth defects. Materials and Methods: In this retrospective cohort study, ultrasound reports and medical records of patients who received an obstetric ultrasound at the University of Iowa Hospitals and Clinics with an identified laterality of the AUA from 1989 to 2007 (n = 405) were reviewed. Rates of sonographic abnormalities between fetuses with a right versus left AUA were compared using Fisher’s exact test. Adjustments for confounding were made using logistic regression modeling. The significance level was set at 0.05. Results: Right AUAs on ultrasound demonstrate higher unadjusted rates of ultrasound abnormalities with a higher percentage of fetuses with >1 additional abnormality (51.1 vs. 37.0%; p = 0.0043). The left AUA group had a significantly higher percentage of isolated AUA (63.0 vs. 48.8%; p = 0.004). In a multivariate analysis, a sonographic right AUA was significantly associated with gastrointestinal (GI) and genitourinary (GU) abnormalities. No other ultrasonographic and umbilical artery Doppler abnormalities, chromosomal defects or postpartum birth defects were significantly associated with a specific laterality of the AUA. Discussion: Our study identified a significant association between a right AUA and concomitant fetal GI and GU abnormalities. Contrary to previous reports, we conclude that laterality of the AUA may prove to be an easily identified early marker of fetal abnormalities.


  

Author Contacts

Mark Santillan, MD
University of Iowa Hospitals and Clinics, Department of Obstetrics and Gynecology
Division of Maternal Fetal Medicine, 31330 PFP, 200 Hawkins Drive
Iowa City, IA 52240 (USA)
Tel. +1 319 356 3180, E-Mail mark-santillan@uiowa.edu

  

Article Information

Received: November 4, 2011
Accepted after revision: March 12, 2012
Published online: June 1, 2012
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 6, Number of References : 28

  

Publication Details

Fetal Diagnosis and Therapy (Clinical Advances and Basic Research)

Vol. 32, No. 3, Year 2012 (Cover Date: November 2012)

Journal Editor: Gratacós E. (Barcelona)
ISSN: 1015-3837 (Print), eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/4/2011 11:31:55 AM
Accepted: 3/12/2012
Published online: 6/1/2012

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 6

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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