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Table of Contents
Vol. 128, No. 2, 2012
Issue release date: August 2012
Section title: Case Report
Acta Haematol 2012;128:83–87
(DOI:10.1159/000338217)

Complete Response of Myeloid Sarcoma with FIP1L1-PDGFRA-Associated Myeloproliferative Neoplasms to Imatinib Mesylate Monotherapy

Tang T.-C.a · Chang H.a · Chuang W.-Y.b
aDivision of Hematology-Oncology, and bDepartment of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: December 08, 2011
Accepted: March 06, 2012
Published online: June 19, 2012
Issue release date: August 2012

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Myeloid sarcoma (MS) is a localized, extramedullary tumor of acute myeloid leukemia (AML) that typically presents either de novo or concomitantly with myeloproliferative neoplasms (MPN), AML and myelodysplastic syndrome. Patients who have MS must be treated with intensive chemotherapy, as are patients with AML, because MS usually progresses to a systemic manifestation and leads to dismal outcomes. FIP1L1-PDGFRA-associated MPN, a subtype of myeloid and lymphoid neoplasm, is characterized by eosinophilia and abnormalities in the PDGFRA, PDGFRB or FGFR1 gene. Fusion of the FIP1L1 and PDGFRA genes activates the tyrosine kinase. As a result, imatinib mesylate (IM) is widely used for the treatment of this disorder. The coexistence of FIP1L1-PDGFRA-associated MPN and MS is extremely rare. Patients with this condition fail to achieve durable remission and long-term survival without a combination of intensive chemotherapy and IM. Here, we report a case of MS and FIP1L1-PDGFRA-associated MPN that was successfully treated with IM monotherapy.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: December 08, 2011
Accepted: March 06, 2012
Published online: June 19, 2012
Issue release date: August 2012

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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