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Vol. 2, No. 1, 2012
Issue release date: January – June
Section title: Published: April 2012

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Case Rep Nephrol Urol 2012;2:20–24
(DOI:10.1159/000338269)

Massive Colchicine Overdose with Recovery

Iosfina I.a · Lan J.b · Chin C.a · Werb R.b · Levin A.b
Departments of aMedicine and bNephrology, University of British Columbia, Vancouver, B.C., Canada
email Corresponding Author

Dr. Ioulia Iosfina

2806–833 Homer StreetVancouver, BC V6B 0H4 (Canada)

Tel. +1 778 839 9456E-Mail jiosfina@gmail.com

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Abstract

Colchicine is an active alkaloid that is commonly used for treatment of multiple diseases including gout, primary biliary cirrhosis and familial Mediterranean fever. Less commonly, it has been implicated in several fatal overdoses. Deaths from colchicine overdoses are usually due to multi-organ failure, whether directly from colchicine toxicity or due to ensuing sepsis. We report an extreme case of colchicine ingestion (1.38 mg/kg), which is the largest reported non-fatal colchicine overdose. The patient was a 47-year-old First Nations woman with a history of depression and no other comorbidities. Ingestion was intentional and initial presentation was within 2 h of ingestion, at which point she had normal clinical and laboratory parameters. Early implementation of a targeted therapeutic strategy directed at the predicted multi-organ failure which included aggressive use of a GI decontamination protocol, timely supportive measures including ventilator support and renal replacement therapy, as well as the utilization of broad-spectrum antibiotics and G-CSF for sepsis and leucopenia management, resulted in successful support and discharge of this patient off dialysis.

© 2012 S. Karger AG, Basel


  

Article Information

Published online: April 11, 2012
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 1,

  

Publication Details

Case Reports in Nephrology and Urology

Vol. 2, No. 1, Year 2012 (Cover Date: January - April)

Journal Editor: Tomino Y. (Tokyo), Tang S. (Hong Kong)
ISSN: 1664-5510 (Print), eISSN: 1664-5510 (Online)

For additional information: http://www.karger.com/CRU


Article / Publication Details

First-Page Preview
Abstract of Published: April 2012

Published online: 4/11/2012
Issue release date: January – June

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: (Print)
eISSN: 2296-9705 (Online)

For additional information: http://www.karger.com/CND


Open Access License / Drug Dosage / Disclaimer

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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