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Table of Contents
Vol. 83, No. 1, 2012
Issue release date: July 2012
Section title: Clinical Study
Oncology 2012;83:10–15
(DOI:10.1159/000338329)

Plasma D-Dimer Level as a Mortality Predictor in Patients with Advanced or Recurrent Colorectal Cancer

Yamamoto M. · Yoshinaga K. · Matsuyama A. · Iwasa T. · Osoegawa A. · Tsujita E. · Yamashita Y. · Tsutsui S. · Ishida T.
aDepartment of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, and bDepartment of Surgery, Yahata Saiseikai General Hospital, Kitakyushu, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 9/27/2011 11:46:45 AM
Accepted: 3/15/2012
Published online: 6/21/2012
Issue release date: July 2012

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 4

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objective: Plasma D-dimer levels are elevated in patients with a variety of solid tumors. Recently, it has been reported that the level before curative surgery is a prognostic factor for colorectal cancer (CRC). We investigated whether the plasma D-dimer level before systemic chemotherapies is a predictor for advanced or recurrent unresectable CRC. Methods: This study included 42 patients treated with systemic chemotherapies for advanced or recurrent unresectable CRC. Variables including clinicopathological factors, plasma D-dimer levels and the modified Glasgow Prognostic Factor Score (mGPS) were evaluated. Results: The plasma D-dimer level was closely related to the mGPS. Survival was shorter for patients with plasma D-dimer levels >5 µg/ml than for those with lower levels. Compared with an mGPS of 0 or 1, an mGPS of 2 was predictive of poor prognosis (p < 0.0001). Old age, advanced stage, plasma D-dimer level and mGPS were significantly associated with mortality, but plasma D-dimer level was the only independent risk factor in multivariate analysis, and was significant related to the clinical response to chemotherapy (p < 0.05). Conclusions: Survival was significantly shorter in patients with elevated plasma D-dimer levels having advanced or recurrent CRC. The plasma D-dimer level before systemic chemotherapies was an independent mortality predictor.


  

Author Contacts

Manabu Yamamoto, MD
Department of Surgery, Yahata Saiseikai General Hospital
5-9-27 Haruno-machi, Higashi-ku, Yahata
Kitakyushu 805-0050 (Japan)
Tel. +81 93 662 5211, E-Mail yamamoto-m@yahata.saiseikai.or.jp

  

Article Information

Received: September 27, 2011
Accepted after revision: March 15, 2012
Published online: June 21, 2012
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 4, Number of References : 45

  

Publication Details

Oncology (International Journal for Cancer Research and Treatment)

Vol. 83, No. 1, Year 2012 (Cover Date: July 2012)

Journal Editor: Markman M. (Philadelphia, Pa.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 9/27/2011 11:46:45 AM
Accepted: 3/15/2012
Published online: 6/21/2012
Issue release date: July 2012

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 4

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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