Hepatic Sarcoidosis Presenting as Portal Hypertension and Liver Cirrhosis: Case Report and Review of the LiteratureTan C.B.a · Rashid S.c · Rajan D.a · Gebre W.b · Mustacchia P.c
Departments of aInternal Medicine, bPathology and cGastroenterology, Nassau University Medical Center, East Meadow, N.Y., USA Corresponding Author
Christopher B. Tan
2201 Hempstead Turnpike
East Meadow, NY 11554 (USA)
Tel. +1 516 572 6501, E-Mail firstname.lastname@example.org
Systemic sarcoidosis is a disease of unknown etiology, with the liver being the third most commonly affected organ. Most cases of hepatic sarcoidosis are not clinically apparent, but a few can progress to liver cirrhosis, portal hypertension and ultimately liver failure. The diagnosis of hepatic sarcoidosis is difficult, considering that no single laboratory test or radiographic finding can definitively diagnose this systemic disease. Diagnosis of hepatic sarcoidosis relies heavily on histopathologic evaluation of two or more organs, a diagnostic modality that is invasive and may not be applicable to all patients. The treatment of hepatic sarcoidosis is challenging, with no large randomized controlled trials done to date. Physicians must be aware of the complications of hepatic sarcoidosis, and must include the same in the differential diagnosis of liver cirrhosis. We present a case of hepatic sarcoidosis complicated by portal hypertension and liver cirrhosis.
© 2012 S. Karger AG, Basel