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Vol. 61, No. 1, 2012
Issue release date: August 2012
Section title: Original Paper
Ann Nutr Metab 2012;61:57–64
(DOI:10.1159/000338440)

Effects of Xylitol on Blood Glucose, Glucose Tolerance, Serum Insulin and Lipid Profile in a Type 2 Diabetes Model of Rats

Islam M.S. · Indrajit M.
Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Westville Campus), Durban, South Africa

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/6/2012
Accepted: 3/29/2012
Published online: 7/20/2012
Issue release date: August 2012

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 1

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Background/Aims: The present study was conducted to examine the antidiabetic effects of xylitol in a type 2 diabetes rat model. Methods: Six-week-old male Sprague-Dawley rats were randomly divided into 3 groups: normal control (NC), diabetic control (DBC) and xylitol (XYL). Diabetes was induced only in the DBC and XYL animal groups by feeding them a 10% fructose solution for 2 weeks followed by an injection (i.p.) of streptozotocin (40 mg/kg body weight). One week after the streptozotocin injection, the animals with a nonfasting blood glucose level of >300 mg/dl were considered to be diabetic. The XYL group was fed further with a 10% xylitol solution, whereas the NC and DBC groups were supplied with normal drinking water. Results: After 5 weeks of intervention, food and fluid intake, body weight, blood glucose, serum fructosamine and most of the serum lipids were significantly decreased, and serum insulin concentration and glucose tolerance ability was significantly increased in the XYL group compared to the DBC group. Liver weight, liver glycogen and serum triglycerides were not influenced by feeding with xylitol. Conclusion: The data of this study suggest that xylitol can be used not only as a sugar substitute but also as a supplement to antidiabetic food and other food products.

© 2012 S. Karger AG, Basel


  

Author Contacts

Md. Shahidul Islam, PhD
Department of Biochemistry, School of Life Sciences
University of KwaZulu-Natal (Westville Campus)
Durban 4000 (South Africa)
Tel. +27 31 260 8717, E-Mail islamd@ukzn.ac.za

  

Article Information

Received: February 6, 2012
Accepted after revision: March 29, 2012
Published online: July 20, 2012
Number of Print Pages : 8
Number of Figures : 5, Number of Tables : 1, Number of References : 40

  

Publication Details

Annals of Nutrition and Metabolism

Vol. 61, No. 1, Year 2012 (Cover Date: August 2012)

Journal Editor: Koletzko B. (Munich)
ISSN: 0250-6807 (Print), eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/6/2012
Accepted: 3/29/2012
Published online: 7/20/2012
Issue release date: August 2012

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 1

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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