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35, No. 5, 2012
Issue release date: May 2012
Onkologie 2012;35:293–299
Review Article · Übersichtsarbeit

First-Line Therapy of Mutated Non-Small Cell Lung Cancer: An Update

Stöhlmacher-Williams J.
Medizinische Klinik und Poliklinik I, Dresden, Germany


Currently, many treatment options and new targets for cancer therapies for patients with advanced non-small cell lung cancer (NSCLC) are being evaluated. This article discusses in detail the significance of first-line and second-line epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and inhibitors of the vascular endothelial growth factor receptor (VEGFR) and EML4-ALK. Furthermore, the article summarizes the implications and future prospects of using molecular testing in the field of NSCLC with focus on EGFR mutations, KRAS mutation, EML4-ALK fusion gene detection, and EGFR expression.

 goto top of outline Author Contacts

PD Dr. med. habil. J. Stöhlmacher-Williams, Medizinische Klinik und Poliklinik I, Fetscherstr. 74, 01307 Dresden, Germany, Tel. +49 351-458 2311, Fax -449 210 630,

 goto top of outline Article Information

Published online: April 24, 2012
Number of Print Pages : 7

 goto top of outline Publication Details

Onkologie (International Journal for Cancer Research and Treatment)

Vol. 35, No. 5, Year 2012 (Cover Date: May 2012)

Journal Editor: Schmoll H.-J. (Halle/Saale), Hallek M. (Köln)
ISSN: 0378-584X (Print), eISSN: 1423-0240 (Online)

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