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Vol. 6, No. 2, 2012
Issue release date: May – August
Section title: Published: May 2012

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Case Rep Gastroenterol 2012;6:309–313

A Case of Autoimmune Hepatitis and Bisphosphonate-Related Osteonecrosis of the Jaw

de Boer Y.S.a · Bouma G.a · Wattjes M.P.b · Lips P.c · Mulder C.J.J.a · van Nieuwkerk C.M.J.a
Departments of aGastroenterology and Hepatology, bRadiology and cEndocrinology, VU University Medical Center, Amsterdam, The Netherlands

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Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease of unknown aetiology usually requiring long-term immunosuppressive therapy. We present the case of an AIH patient who received long-term corticosteroids and azathioprine. As treatment for concomitant osteoporosis she was also treated with potent intravenous bisphosphonate (BP). This treatment was complicated by the development of BP-related osteonecrosis of the jaw (BRONJ). BRONJ is an uncommon complication of BP treatment regimes that occurs at increased frequency in the presence of other risk factors, including chronic inflammatory conditions. Our patient suffered from a severe and complicated clinical course of BRONJ which, despite adequate therapy, resulted in death of the patient. Here we discuss the risk factors for the development and clinical course of BRONJ in AIH and the implications for management of these patients.

© 2012 S. Karger AG, Basel


Article / Publication Details

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Abstract of Published: May 2012

Published online: 5/23/2012
Issue release date: May – August

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: (Print)
eISSN: 1662-0631 (Online)

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Open Access License / Drug Dosage

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (, applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
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