Monogamous and Promiscuous Rodent Species Exhibit Discrete Variation in the Size of the Medial Prefrontal CortexKingsbury M.A. · Gleason E.D. · Ophir A.G. · Phelps S.M. · Young L.J. · Marler C.A.
aDepartment of Biology, Indiana University, Bloomington, Ind., bDepartment of Psychology, University of Wisconsin-Madison, Madison, Wisc., cDepartment of Zoology, Oklahoma State University, Stillwater, Okla., dSection of Integrative Biology, University of Texas at Austin, Austin, Tex., and eCenter for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, Ga., USA
Limbic-associated cortical areas, such as the medial prefrontal and retrosplenial cortex (mPFC and RS, respectively), are involved in the processing of emotion, motivation, and various aspects of working memory and have been implicated in mating behavior. To determine whether the independent evolution of mating systems is associated with a convergence in cortical mechanisms, we compared the size of mPFC and RS between the monogamous prairie vole (Microtus ochrogaster) and the promiscuous meadow vole (Microtus pennsylvanicus), and between the monogamous California mouse (Peromyscus californicus) and the promiscuous white-footed mouse (Peromyscus leucopus). For both promiscuous mice and voles, the mPFC occupied a significantly larger percentage of total cortex than in the monogamous species. No significant differences were observed for the RS or overall cortex size with respect to mating system, supporting the convergent evolution of mPFC size, specifically. Individual differences in the mating behavior of male prairie voles (wandering versus pair-bonding), presumably facultative tactics, were not reflected in the relative size of the mPFC, which is likely a heritable trait. Given the importance of the mPFC for complex working memory, particularly object-place and temporal order memory, we hypothesize that the relatively greater size of the mPFC in promiscuous species reflects a greater need to remember multiple individuals and the times and locations in which they have been encountered in the home range.
Marcy A. Kingsbury
Department of Biology, Indiana University
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Received: October 31, 2011
Returned for revision: November 26, 2011
Accepted after revision: May 1, 2012
Published online: June 30, 2012
Number of Print Pages : 11
Number of Figures : 3, Number of Tables : 1, Number of References : 86
Brain, Behavior and Evolution
Vol. 80, No. 1, Year 2012 (Cover Date: August 2012)
Journal Editor: Striedter G.F. (Irvine, Calif.)
ISSN: 0006-8977 (Print), eISSN: 1421-9743 (Online)
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