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Vol. 33, No. 4, 2012
Issue release date: July 2012
Dement Geriatr Cogn Disord 2012;33:266–272
Original Research Article

Association between BDNF Polymorphism (Val66Met) and Executive Function in Patients with Amnestic Mild Cognitive Impairment or Mild Alzheimer Disease

Nagata T.a–c · Shinagawa S.a · Nukariya K.c · Yamada H.b · Nakayama K.a
aDepartment of Psychiatry and bDivision of Molecular Genetics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, and cDepartment of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Japan


Background: In the present study, we examined whether brain-derived neurotrophic factor (BDNF) polymorphism (Val66Met) influenced the changeable executive dysfunction of patients with two separate disease stages: amnestic mild cognitive impairment (A-MCI) or mild Alzheimer disease (AD), which are comparatively similar demented conditions. Methods: Among 200 outpatients with dementia and MCI, 146 outpatients with mild AD or A-MCI were recruited and divided into two genotypic groups, valine homozygosity (Val/Val) and methionine (Met) carriers, based on the representative BDNF functional polymorphism Val66Met. Next, we compared the Frontal Assessment Battery (FAB) total and subtest scores between the two genotypic groups according to each of two different disease stages: A-MCI (n = 42) and mild AD (n = 104). Results: Among patients with only a mild stage of AD, the FAB total and go/no-go scores were significantly lower (p < 0.05) among the subjects with the Val/Val genotype than among the Met carriers. However, no significant differences in any other demographic variables were observed between the genotypes according to each of different disease stages. A significant interaction between Val66Met and age was not observed for the FAB scores. Conclusion: These results suggested that the BDNF gene may significantly influence executive dysfunction, including inhibition tasks, among patients with mild-stage AD.

 goto top of outline Author Contacts

Tomoyuki Nagata
Department of Psychiatry, Jikei University School of Medicine
3-25-8 Nishishimbashi, Minato-ku
Tokyo 105–8471 (Japan)
Tel. +81 3 3433 1111, E-Mail

 goto top of outline Article Information

Accepted: May 2, 2012
Published online: June 13, 2012
Number of Print Pages : 7

 goto top of outline Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 33, No. 4, Year 2012 (Cover Date: July 2012)

Journal Editor: Chan-Palay V. (Boston, Mass.)
ISSN: 1420-8008 (Print), eISSN: 1421-9824 (Online)

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