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Table of Contents
Vol. 128, No. 4, 2012
Issue release date: November 2012
Section title: Original Paper
Acta Haematol 2012;128:203–212
(DOI:10.1159/000339506)

Prognostic Impact of NPM1 Mutations in Serbian Adult Patients with Acute Myeloid Leukemia

Kuzmanovic M.c · Tosic N.a · Colovic N.d · Karan-Djurasevic T.a · Spasovski V.a · Radmilovic M.a · Nikcevic G.a · Suvajdzic-Vukovic N.b, d · Tomin D.b, d · Vidovic A.b, d · Virijevic M.d · Pavlovic S.a · Colovic M.b
aInstitute of Molecular Genetics and Genetic Engineering, and bMedical Faculty, University of Belgrade, cDepartment of Hematology, Mother and Child Healthcare Institute ‘Dr. Vukan Cupic’, and dClinic for Hematology, Clinical Center of Serbia, Belgrade, Serbia

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 20, 2011
Accepted: May 15, 2012
Published online: August 15, 2012
Issue release date: November 2012

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 4

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Based on current findings, the presence of NPM1 mutations in acute myeloid leukemia (AML) patients is associated with an increased probability of complete remission (CR) and better overall survival (OS). We determined the incidence and prognostic relevance of NPM1 mutations, their association with FLT3 and IDH mutations, and other clinical characteristics in Serbian adult AML patients. Samples from 111 adult de novo AML patients, including 73 AML cases with a normal karyotype (NK-AML), were studied. NPM1, FLT3, and IDH mutations were detected by PCR and direct sequencing. NPM1 mutations were detected in 22.5% of patients. The presence of NPM1 mutations predicted a low CR rate and shorter OS. NPM1 mutations showed an association with both FLT3 and IDH mutations. Survival analysis based on NPM1/FLT3 mutational status revealed a lower OS for NPM1+/FLT3 compared to the NPM1/FLT3 group in NK-AML patients. The lack of impact or unfavorable prognostic effect of NPM1 mutations found in this study can be assigned to a small cohort of analyzed AML patients, as can the presence of FLT3 and IDH mutations or other genetic lesions that cooperate with NPM1 mutations influencing prognosis.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 20, 2011
Accepted: May 15, 2012
Published online: August 15, 2012
Issue release date: November 2012

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 4

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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