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Vol. 5, No. 2, 2012
Issue release date: May – August
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Case Rep Oncol 2012;5:325–331
(DOI:10.1159/000339721)
Published: June 2012

Disseminated Intracranial Ewing’s Sarcoma in an Adult:A Rare and Difficult Diagnosis

Lou E.a · Sumrall A.L.a · Cummings T.J.a · Korones D.N.b · Weaver S.A.c · Peters K.B.a
aThe Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, N.C., bUniversity of Rochester Medical Center, Rochester, N.Y., and cAlbany Medical Center, New York, N.Y., USA

Abstract

The Ewing sarcoma family of tumors comprises a rare class of cancers of mesenchymal origin. Cases of Ewing’s sarcoma in the central nervous system – specifically, intracranial Ewing’s – are extremely rare. Almost all reported cases have occurred in children. However, this rare presentation can also occur in the adult population. It is important to distinguish these tumors from primitive neuroectodermal tumors at the time of diagnosis. Testing for EWSR1(22q12) gene rearrangement using fluorescence in situ hybridization is a useful tool for making the distinction between these 2 similar but distinct entities. We present here the case of a middle-aged male patient with intracranial Ewing’s sarcoma, and discuss diagnostic challenges and potential new treatment approaches for this rare disease.

 goto top of outline Author Contacts

Emil Lou, MD, PhD
Division of Hematology, Oncology and Transplantation
MMC Code 480, 420 Delaware Street SE
Minneapolis, MN 55455 (USA)
Tel. +1 612 625 1110, E-Mail emil-lou@umn.edu


 goto top of outline Article Information

Published online: June 21, 2012
Number of Print Pages : 7
Number of Figures : 3,


 goto top of outline Publication Details

Case Reports in Oncology

Vol. 5, No. 2, Year 2012 (Cover Date: May - August)

Journal Editor: Markman M. (Philadelphia, Pa.)
ISSN: 1662-6575 (Print), eISSN: 1662-6575 (Online)

For additional information: http://www.karger.com/CRO


Open Access License / Drug Dosage

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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