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Table of Contents
Vol. 56, No. 6, 2012
Issue release date: November – December
Section title: Paper
Acta Cytologica 2012;56:611–621
(DOI:10.1159/000339792)

Role of Fluorescence in situ Hybridization in Lung Cancer Cytology

Savic S. · Bubendorf L.
Division of Cytopathology, Institute for Pathology, University Hospital Basel, Basel, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: January 26, 2012
Accepted: April 16, 2012
Published online: December 01, 2012
Issue release date: November – December

Number of Print Pages: 11
Number of Figures: 6
Number of Tables: 0

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY

Abstract

There are several challenges in lung cytology including equivocal cytological findings, lung cancer subclassification, and predictive marker analysis. Fluorescence in situ hybridization (FISH) detects chromosomal alterations that underlie the development and progression of cancer, and pinpoints targets of new anticancer drugs. Detection of such targets by FISH can be of diagnostic utility in morphologically difficult cases. Multitarget FISH with four different chromosomal probes improves the sensitivity of cytology in the diagnosis of lung cancer and clarifies equivocal cytological findings. FISH is becoming increasingly important in the field of predictive marker analysis. FISH is the gold standard to identify ALK rearrangements for treatment with the ALK inhibitor crizotinib (Xalkori). EGFR mutation analysis is the method of choice for selecting patients for therapy with EGFR tyrosine kinase inhibitors (TKIs), whereas the EGFR gene copy number has not been confirmed as a reliable predictive marker. MET amplification is an important mechanism of secondary resistance to EGFR TKIs and a candidate predictive marker for targeted second-line treatment of TKI-resistant non-squamous non-small cell lung cancer. FGFR1 amplification is a promising new marker in squamous cell carcinoma that may predict the response to FGFR1 inhibitors. In conclusion, there are an increasing number of clinically relevant FISH applications in lung cytology. We provide an overview on the current role of FISH in respiratory cytology.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: January 26, 2012
Accepted: April 16, 2012
Published online: December 01, 2012
Issue release date: November – December

Number of Print Pages: 11
Number of Figures: 6
Number of Tables: 0

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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