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Complete and Sustained Objective Response per RECIST to Irvalec (PM02734) in Undifferentiated Large Cell Esophageal Adenocarcinoma: A Case Report and a Review of the LiteratureSalazar R.a · Cuadra C.a · Gil-Martín M.a · Vandermeeren A.b · Alfaro V.b · Coronado C.b
aInstituto Catalán de Oncología-IDIBELL, Barcelona, and bPharmaMar, Colmenar Viejo, Spain Corresponding Author
Ramón Salazar, MD
Instituto Catalán de Oncología-IDIBELL
Avda. Gran Via 199–203
ES–08907 L’Hospitalet de Llobregat, Barcelona (Spain)
Tel. +34 93 260 7739, E-Mail email@example.com
Undifferentiated large cell carcinoma is a rare entity in esophageal cancer and very few data are available in the literature on this uncommon histological subtype. We report a case of a 58-year-old Caucasian male previously treated with cisplatin/5-fluorouracil, docetaxel and carboplatin/plitidepsin who received treatment with a novel antitumor agent, Irvalec (PM02734), as fourth line. The patient received treatment from July 2006 to July 2009, a total of 49 cycles, at a dose of 2.4 mg/m2 as a 24-hour infusion every 3 weeks. He did not present severe complications or unplanned or cumulative toxicities. Complete and durable response according to RECIST was reported. He was alive at the last follow-up on March 2012.
© 2012 S. Karger AG, Basel