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Vol. 78, No. 2, 2012
Issue release date: September 2012
Section title: Original Paper
Horm Res Paediatr 2012;78:94–99
(DOI:10.1159/000341151)

Quality of Life in Children and Adolescents with Growth Hormone Deficiency: Association with Growth Hormone Treatment

Geisler A. · Lass N. · Reinsch N. · Uysal Y. · Singer V. · Ravens-Sieberer U. · Reinehr T.
aDepartment of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Datteln, and bDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/4/2012 1:37:36 PM
Accepted: 6/18/2012
Published online: 8/14/2012

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 4

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Background: Quality of life (QoL) as it is related with growth hormone deficiency (GHD) is a matter of controversy. Methods: We analyzed QoL in 95 children aged 8–18 years with isolated GHD (72% male) treated with growth hormone (GH). These children were compared to 190 age- and gender-matched healthy children with similar height [height <10th percentile; control group 1 (CG1)] and age- and gender-matched 285 healthy children of normal stature (control group 2: CG2). QoL was measured by the KINDL® questionnaire referring to six domains (physical well-being, emotional well-being, self-esteem, family, friends, and school). Results: QoL was significantly reduced in CG1 (effect-size 0.21) compared to CG2, while QoL was not significantly altered in children with GHD. In multiple linear regression analyses adjusted to age, gender, BMI, migration background, and socioeconomic status, decreasing height-SDS was associated with poorer QoL (especially emotional well-being), and treatment with GH was related significantly to better self-esteem. Increase of height-SDS in children treated with GH was associated positively with QoL and all its subscales except family and school. Conclusions: These findings suggest psychological consequences of short stature in children and an improvement of QoL in children treated with GH with the focus on self-esteem and emotional well-being.


  

Author Contacts

Prof. Dr. Thomas Reinehr, Department of Pediatric Nutrition Medicine
Vestische Hospital for Children and Adolescents Datteln
University of Witten/Herdecke, Dr. F. Steiner Strasse 5
DE–45711 Datteln (Germany)
Tel. +49 236 397 5229, E-Mail T.Reinehr@kinderklinik-datteln.de

  

Article Information

Received: April 4, 2012
Accepted: June 18, 2012
Published online: August 14, 2012
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 4, Number of References : 37

  

Publication Details

Hormone Research in Paediatrics (From Developmental Endocrinology to Clinical Research)

Vol. 78, No. 2, Year 2012 (Cover Date: September 2012)

Journal Editor: Czernichow P. (Paris)
ISSN: 1663-2818 (Print), eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/4/2012 1:37:36 PM
Accepted: 6/18/2012
Published online: 8/14/2012

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 4

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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