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Table of Contents
Vol. 56, No. 5, 2012
Issue release date: September – October
Section title: Nongynecologic Cytopathology
Acta Cytologica 2012;56:543–547
(DOI:10.1159/000341425)

The Role of Urine Cytology for ‘Decoy Cells’ as a Screening Tool in Renal Transplant Recipients

Ranzi A.D. · Prolla J.C. · Keitel E. · Brackmann R. · Kist R. · dos Santos G.T. · Bica C.G.
Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil

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Article / Publication Details

First-Page Preview
Abstract of Nongynecologic Cytopathology

Received: December 01, 2011
Accepted: June 27, 2012
Published online: September 27, 2012
Issue release date: September – October

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY

Abstract

Objective: To determine the role of urine cytology for ‘decoy cells’ as a screening tool for polyomavirus type BK (BKV) infection in renal transplant recipients. Study Design: This was a prospective cohort study of patients undergoing renal transplantation between 2006 and 2010. Results: A total of 442 patients underwent urine cytology for decoy cells, 27.8% underwent 1 examination only and 72.2% more than one. Of the 1,713 examinations reviewed, 426 (24.9%) were positive and 785 (45.8%) were negative for ‘decoy’ cells, 380 (22.2%) showed degenerated tubular cells and 122 (7.1%) were unsatisfactory for analysis. Urine cytology was found to have a specificity of 68.5%, a sensitivity of 84.6%, a positive predictive value of 21.2%, a negative predictive value of 97.8% and an overall accuracy of 69.9%. The incidence of polyomavirus nephropathy among the patients investigated was 11.8%. Of the 442 patients, 32 (7.2%) had graft loss, which was attributed to BKV nephropathy in 2 (6.2% of the 32). Conclusions: Urine cytology is an effective screening method for monitoring renal transplant patients, with high sensitivity and a high negative predictive value, and can therefore be used routinely in the follow-up of renal transplant patients.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Nongynecologic Cytopathology

Received: December 01, 2011
Accepted: June 27, 2012
Published online: September 27, 2012
Issue release date: September – October

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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