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30, No. 4, 2012
Issue release date: September 2012
Section title: Review
Cell Physiol Biochem 2012;30:953-963
(DOI:10.1159/000341472)

NOD2 Signaling and Role in Pathogenic Mycobacterium Recognition, Infection and Immunity

Deng W. · Xie J.
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing

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Abstract

The Mycobacterium pathogens acquire additional properties to expand their pathogenicity and existence spaces. The interaction between pathogenic Mycobacterium components and receptors of host innate immune system is critical for the infection outcome, particularly for the macrophage activation. NOD2 (Nucleotide binding oligomerization domain 2), an intracellular pathogen recognition sensor, attenuates two key putative host bacterial killing mechanisms: interfering the production of TNF-alpha and inducing resistance to apoptosis. Multiple evidences have shown that NOD2 acts as a non-redundant recognition system of Mycobacterium, a successful pathogen with many mechanisms to evade host immunity and leading to insidious disease. Understanding the complex interaction between host and pathogen mediated by NOD2 signaling, might provide novel insight into the pathogenesis of pathogenic Mycobacterium and inform the development of more effective vaccines and therapeutics.

© 2012 S. Karger AG, Basel


  

Author Contacts

Jianping Xie
Institute of Modern Biopharmaceuticals,
State Key Laboratory Breeding Base of Eco-Environment
and Bio-Resource of the Three Gorges Area,
School of Life Sciences, Southwest University, Beibei, Chongqing 400715 (China)
Tel. & Fax 862368367108, E-Mail dwy2011@swu.edu.cn

  

Article Information

Accepted: August 03, 2012
Published online: September 13, 2012
Number of Print Pages : 11

  

Publication Details

Cellular Physiology and Biochemistry (International Journal of Experimental Cellular Physiology, Biochemistry and Pharmacology)

Vol. 30, No. 4, Year 2012 (Cover Date: September 2012)

Journal Editor: Guggino W. (Baltimore, Md.), Lang F. (Tübingen)
ISSN: 1015-8987 (Print), eISSN: 1421-9778 (Online)

For additional information: http://www.karger.com/CPB


Article / Publication Details

First-Page Preview
Abstract of Review

Accepted: 8/3/2012
Published online: 9/13/2012
Issue release date: September 2012

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-8987 (Print)
eISSN: 1421-9778 (Online)

For additional information: http://www.karger.com/CPB


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