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Vol. 83, No. 4, 2012
Issue release date: August 2012
Section title: Clinical Study
Oncology 2012;83:228–233
(DOI:10.1159/000341537)

Male Breast Cancer: Immunohistochemical Subtypes and Clinical Outcome Characterization

Sánchez-Muñoz A. · Román-Jobacho A. · Pérez-Villa L. · Sánchez-Rovira P. · Miramón J. · Pérez D. · Sáez M.-I. · de Luque V. · Medina L. · Ramírez-Tortosa C.L. · Vicioso L. · Medina J.A. · Ribelles N. · Alba E.
aMedical Oncology Service and Departments of bRadiation Oncology and cPathology, Hospital Universitario Virgen de la Victoria, Málaga, dMedical Oncology Service and eDepartment of Pathology, Complejo Hospitalario de Jaén, Jaén, fMedical Oncology Service, Hospital de la Serranía, Ronda, and gMedical Oncology Service, Hospital Costa del Sol, Marbella, Spain

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 5/18/2012 9:59:45 AM
Accepted: 6/27/2012
Published online: 8/16/2012

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Aim: The aim of this study was to assess the molecular subtype profiles of male breast cancer (MBC) and subsequent clinical outcome using a validated 6-marker immunohistochemical panel. Methods: A total of 43 cases of MBC were examined retrospectively using a semiquantitative immunohistochemical analysis of estrogen receptor (ER), progesterone receptor (PR), Ki-67, human epidermal growth factor receptor 2 (Her2), epidermal growth factor receptor and cytokeratin 5/6. Patients were classified into the following categories: luminal A, luminal B, Her2-positive or basal-like subtypes. Results: The median age of patients was 63 years (r: 32–89). The predominant histology was invasive ductal carcinoma (91%). Only 1 patient had advanced breast cancer at diagnosis. Ninety-three percent were ER-positive and 84% were PR-positive. Two patients had tumors that were ER- and PR-negative. The distribution of tumor molecular subtypes was 19 (44%) luminal A, 22 (51%) luminal B and 2 (5%) basal-like. The Her2-positive tumor subtype was not identified. The clinicopathological characteristics did not differ significantly between tumor subtypes A and B. There were no significant differences in 6-year disease-free survival (74 vs. 82%, p = 0.77) or overall survival (74 vs. 82%, p = 0.69) between luminal A and luminal B subtypes, respectively. Conclusion: The most common subtypes in our cohort of MBC were luminal B followed by luminal A, and no differences were found between both tumor subtypes in terms of clinicopathologic characteristics and patient outcome.


  

Author Contacts

Alfonso Sánchez-Muñoz, MD
Medical Oncology Service, Hospital Universitario Virgen de la Victoria
Campus Teatinos s/n
ES–29010 Málaga (Spain)
Tel. +34 95 103 24 69, E-Mail asmoncomed@yahoo.es

  

Article Information

Received: May 18, 2012
Accepted after revision: June 27, 2012
Published online: August 16, 2012
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 2, Number of References : 25

  

Publication Details

Oncology (International Journal for Cancer Research and Treatment)

Vol. 83, No. 4, Year 2012 (Cover Date: August 2012)

Journal Editor: Markman M. (Philadelphia, Pa.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 5/18/2012 9:59:45 AM
Accepted: 6/27/2012
Published online: 8/16/2012

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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