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Utility of Maoto in an Influenza Season Where Reduced Effectiveness of Oseltamivir Was Observed – a Clinical, Non-Randomized Study in ChildrenToriumi Y.a,b · Kamei T.c,d · Murata K.d,e · Takahashi I.a · Suzuki N.e · Mazda O.b
a Department of Pediatrics, Ohmura Hospital, Chiba, b Department of Microbiology and Immunology, Kyoto Prefectural University of Medicine, Kyoto, Japan c European University Viadrina, Frankfurt, Germany d Department of Medical Research, Shimane Institute of Health Science, Shimane, e Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
Background: In an influenza season where reduced effectiveness of oseltamivir was observed, we investigated the effectiveness of Maoto for influenza infection in children. Methods: Patients diagnosed with influenza by rapid diagnostic kit underwent treatment in one of the following groups: Maoto-treated group (group 1 (M)); oseltamivir-treated group (group 2 (O)); Maoto+oseltamivir-treated group (group 3 (M+O)); zanamivir-treated group (group 4 (Z)); and Maoto+zanamivir-treated group (group 5 (M+Z)). Results: In influenza A patients who completed the study (n = 150), the mean duration of fever after administration (DFA) was significantly shorter in group 3 (M+O) (31.1 h, p < 0.01) and in group 4 (Z) (35.2 h, p < 0.05), as compared to group 2 (O) (56.0 h). Among these, in patients aged ≤5 years (n = 54), DFA was significantly shorter in group 1 (M) (33.2 h, p < 0.05) and in group 3 (M+O) (34.6 h, p < 0.05), as compared to group 2 (O) (61.4 h). In influenza B patients who completed the study (n = 70), no significant differences in DFA were observed among the groups. Conclusion: Maoto may be useful, particularly in cases of influenza with low sensitivity to oseltamivir and in patients aged ≤5 years for whom the use of zanamivir is difficult.
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