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Vol. 4, No. 2, 2012
Issue release date: May – August
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Case Rep Dermatol 2012;4:163–169
Published: August 2012

Multicentric Reticulohistiocytosis Associated with Liver Carcinoma: Report of a Case

Han L. · Huang Q. · Liao K.-H. · Chen L.-J. · Kong W.-Y. · Fu W.-W. · Xu J.
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, PR China


We report a unique case of multicentric reticulohistiocytosis (MRH) associated with liver carcinoma. A 61-year-old man presented with a 4-month history of nonpruritic, generalized, ruby-red papules and nodules, accompanied by fever, joint swelling and difficulty in swallowing. Skin histology showed polymorphic histiocyte infiltration with typical ‘ground glass’ cytoplasm. Further immunohistochemical studies characterized the lesions as positive for leukocyte common antigen, HLA-DR and CD68. The patient had a history of hepatitis B, and systemic examination, including carcinoma index and type-B ultrasonic examination, revealed high levels of AFP and a solid tumor, which was considered malignant, localized on the right lobe of the liver. Treatment of the liver carcinoma resulted in a significant improvement of the skin symptoms. This is the first case study to report an association between MRH and liver carcinoma. A review of the English-language literature reveals the close linkage between MRH and malignancy. All patients with MRH should be evaluated and monitored carefully to determine the underlying neoplasm.

 goto top of outline Author Contacts

Lian-Jun Chen
Department of Dermatology, Huashan Hospital

12 Wulumuqi Middle Road
Shanghai 200040 (PR China)
Tel. +86 21 5288 7783, E-Mail

 goto top of outline Article Information

Published online: August 1, 2012
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 1,

 goto top of outline Publication Details

Case Reports in Dermatology

Vol. 4, No. 2, Year 2012 (Cover Date: May - August)

Journal Editor: Jemec G.B.E. (Roskilde)
ISSN: 1662-6567 (Print), eISSN: 1662-6567 (Online)

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